Nerve Growth Factor and Vascular Endothelial Growth Factor: Retrospective Analysis of 63 Patients with Salivary Adenoid Cystic Carcinoma

Hao Li; Xiao-lin Nong; Qi Chen; Yi-ping Yang; Jia-quan Li; Yan-ning Li

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Nerve Growth Factor and Vascular Endothelial Growth Factor: Retrospective Analysis of 63 Patients with Salivary Adenoid Cystic Carcinoma

机译：神经生长因子和血管内皮生长因子：63例涎腺腺样囊性癌患者的回顾性分析

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Aim To detect the expression of nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) in salivary adenoid cystic carcinoma (SACC) tissues, as well as to determine the correlation between growth factor expression and prognosis in SACC. Methodology Medical records of 63 patients surgically treated for SACC between January 1988 and October 2005 were reviewed. Immunohistochemistry was performed to examine the expression of NGF and VEGF in tumor tissues. Kaplan-Meier analysis and Cox's proportional hazard regression model were applied to assess predictors of survival. Results NGF and VEGF were overexpressed in SACC tissues, compared with those in normal salivary tissues (P<0.05), and the staining intensity of these two factors was stronger in groups of solid subtype, advanced TNM stage, perineural invasion and recurrence. Patients with high-expression of NGF and VEGF, solid subtype, advanced stage, perineural invasion, recurrence and extended resection alone had worse survival rates (P<0.05). Conclusion NGF and VEGF are expressed increasingly in the tissues of SACC cases with invasion and metastasis. NGF expression and VEGF expression are independent prognosis factors for survival.

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《国际口腔科学杂志（英文版）》 |2010年第1期|35-44|共10页
作者
Hao Li; Xiao-lin Nong; Qi Chen; Yi-ping Yang; Jia-quan Li; Yan-ning Li;
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Department of Oral and Maxillofacial Surgery,College of Stomatology,Guangxi Medical University,Nanning,China;

Department of Oral and Maxillofacial Surgery,College of Stomatology,Guangxi Medical University,Nanning,China;

Department of Oral and Maxillofacial Surgery,College of Stomatology,Guangxi Medical University,Nanning,China;

Department of Pathology,Stomatological Hospital Affiliated to Guangxi Medical University,Nanning,China;

Laboratory Center,Guangxi Medical University,Nanning,China;

Department of Epidemiology and Health Statistics,College of Public Health,Guangxi Medical University,Nanning,China;

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Nerve Growth Factor and Vascular Endothelial Growth Factor: Retrospective Analysis of 63 Patients with Salivary Adenoid Cystic Carcinoma

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