A case of Rosai-Dorfman disease (RDD) of frontal bone was treated with clinical pathological analysis and immunohistochemistry, and literatures were reviewed. Histopathologically, the disease demonstrated that histiocytes phagocytized lymphocytes, plasma cells, erythrocytes, or polymorphonuclear leukocytes; immunohistochemical analysis demonstrated that S-100 protein and CD68 were positive, CDla was negative. RDD of frontal bone is lack of specific clinical manifestations but numbness of the scalp and forehead. The diagnosis depends on pathological examination. Early surgical resection of the lesion has a good prognosis.%对1例额骨Rosai-Dorfman病(Rosai-Dorfman disease,RDD)进行病理学观察及免疫组织化学分析,并复习相关文献.病理检查可见组织细胞吞噬淋巴细胞、浆细胞、红细胞或中性粒细胞;免疫组织化学示:S-100蛋白阳性,CD68阳性,CDla阴性.额骨RDD除头皮及额部麻木外缺乏特异性临床表现,确诊有赖于病理学检查,早期手术切除病灶预后良好.
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