P物质是一种重要的神经肽,其受体主要是神经激肽受体1(neurokinin receptors 1,NK1-R).P物质在多种感染中发挥作用.P物质受体拮抗剂阿瑞吡坦有抗HIV-1的作用.利用宿主蛋白抗病毒的机制不依赖于病毒DNA聚合酶,减少了病毒耐药的可能.%Substance P (SP) is an important neuropeptide, and its receptor is mainly neurokinin receptors 1 (NK1-R). SP plays a role in the process of multiple viral infections. Aprepitant, which is a SP receptor antagonist, has anti-HIV-1 effect. The anti-viral mechanism of host protein does not depend on the virus DNA polymerase, and thus reduces the possibility of drug resistance.
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