In recent years,the study of the pathogenesis and molecular subtypes of colorectal cancer is becoming more and more deeply.There are two subtypes of colorectal cancer (CRC) depending on the mutation load:hypermutated subtype and non-hypermutated subtype.The hypermutated CRC including microsatellite instable CRC and POLE mutated CRC.The non-hypermutated CRC mainly refers to chromosomally instable CRC.%近年来,人们对结直肠癌(colorectal cancer,CRC)发病机制及分子分型的研究日渐深入.根据CRC基因突变负荷的不同可将其分为高突变型CRC和非高突变型CRC.高突变型CRC包括微卫星不稳定型(microsatellite instability,MSI)CRC和POLE基因突变型CRC,非高突变型CRC主要指染色体不稳定(chromosomal instability,CIN)型CRC.
展开▼
