本文综述维生素D预防和治疗血管钙化方面的研究进展。主要综述了国内外的相关文献对维生素D的抗血管钙化作用和最新研究，基础实验和临床观察都显示维生素D对血管钙化具有重要的调控作用，目前主要研究热点是维生素D抑制血管平滑肌细胞(vascular smooth muscle cell，VSMC)的表型转化，主要问题是维生素D在血管钙化中对血管平滑肌细胞表型的调控作用，且其发挥血管保护作用的机制尚需更多的研究验证。%This paper reviews the research progress of prevention and treatment of vitamin D in vascular calcification. We review the latest research about related domestic and overseas literature about vitamin D resistant vascular calciifcation. Basic experiments and clinical observations showed that vitamin D plays an important regulation role in vascular calcification. At present, the main researches focus on vitamin D suppressing the phenotype transformation of vascular smooth muscle cell, the main problem is the role of vitamin D in the regulation of vascular calciifcation of vascular smooth muscle cell phenotype, and more researches are needed to verify its role in the mechanism of vascular protection.
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