Objective: To explore the characteristics of clinicopathology and diagnostic criteria about right cardiac myxoma. Methods: Analysed the features of clinicopathology and immunohistochemistry of 2 cases, and reviewed the literatures to investigate the diagnosis and its differential diagnosis.Results: Microscopically, mucus tumor cells were isolated, the funicular or arranged in a ring structure of blood vessel formation, myxoid matrix form haloes around blood vessels; the differentiation of tumor cells to form the original or vascular trend, lymphocytic and plasma cell infiltrates in the substrate; tumor cells elongated, fusiform or stellate, eosinophilic cytoplasm and nucleus ovoid, round or elongated; tumor cell aggregation spherical, eosinophilic cytoplasm and nucleus ovoid or fusiform.Conclusion: Right cardiac myxoma is very rare and lack of awareness, thus easily confused with other tumor leading to misdiagnosis. It is essential to avoid misdiagnosis with raising awareness.%目的：探讨右心房黏液瘤的临床病理学特点及诊断要点。方法：对2例右心房黏液瘤进行临床资料、病理形态学及免疫组织化学观察，并结合文献对其诊断及鉴别诊断进行探讨。结果：镜下黏液瘤细胞呈单个散在、条索状或呈血管形成的指环样结构排列，黏液样基质在血管周围形成晕环；瘤细胞形成原始或分化的血管趋势，基质内淋巴细胞、浆细胞浸润；瘤细胞细长、梭形或星状，胞浆嗜酸性，胞核卵圆形、圆形或细长形；瘤细胞聚集呈球状，胞浆嗜酸性，胞核卵圆形或梭形。结论：右心房黏液瘤，非常少见，因此缺乏对其认识，从而易与其他肿瘤混淆导致误诊。提高对心房黏液瘤的认识，对避免误诊是至关重要的。
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