目的：比较洛铂单药用于局部晚期鼻咽癌(nasopharyngeal carcinoma，NPC)同步放化疗与顺铂(cisplatin，CDDP)、5-氟尿嘧啶(fluorouracil，5-FU)联合方案同步放化疗的疗效及毒副反应。方法：101例局部晚期NPC分为两组，49例接受CDDP+5-FU联合方案同步放化疗(PF组)，52例接受洛铂单药同步放化疗(L组)，比较近期疗效、5年生存率及放疗期间毒副反应。结果：PF、L两组患者放疗一月后客观有效率分别为95.9%、96.2%(P=0.889)，5年生存率分别为53.1%、55.8%(P=0.921)，毒副反应恶心呕吐和口腔黏膜反应PF组均较L组明显(P<0.05)。结论：洛铂单药用于局部晚期NPC同步放化疗与CDDP+5-FU联合方案同步放化疗的疗效近似，总生存率无统计学差异，洛铂单药组的恶心呕吐、口腔黏膜反应较轻。%Object:To investigate the efficacy and adverse effects between lobaplatin alone and cisplatin (CDDP) combination with lfuorouracil (5-FU) plus concurrent radiotherapy for local-regionally advanced nasopharyngeal carcinoma. Methods:A total of 101 patients with local-regionally advanced nasopharyngeal carcinoma were divided into two groups, 49 patients received CDDP combination with 5-FU and 52 patients were given lobaplatin alone (group L), respectively, plus concurrent radiotherapy. Compared of the two groups with short-term effects, 5 years survival rate and adverse effects during radiotherapy. Results:A month after radiotherapy, objective response rate was 95.9%for group PF and 96.2%for group L (P=0.889), and 5 years survival rate was 53.1%vs. 55.8%(P=0.921), respectively. Adverse effects, including nausea, vomiting and oral mucosa reaction, in group PF were more obvious than group L (P<0.05). Conclusion:hTe effcacy between lobaplatin alone and CDDP combination with 5-FU plus concurrent radiotherapy for local-regionally advanced nasopharyngeal carcinoma was similar. Total survival rate between two groups had no signiifcant difference. Nausea, vomiting and oral mucosa reaction in group L were signiifcantly lower than group PF.
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