环二腺嘌呤核苷酸(c-di-AMP)是在继环腺嘌呤核苷酸(cAMP)、四(五)磷酸鸟嘌呤核苷((p)ppGpp)、环二鸟嘌呤核苷酸(c-di-GMP)后新发现的一种第二信使分子,在细菌和支原体中广泛存在.c-di-AMP调控细菌多项生理活动,如细胞周期、细胞壁稳定性、细胞形态、刺激宿主免疫反应以及应对外界环境胁迫等.本文总结了信使分子c-di-AMP自发现以来的研究进展,这些信息可丰富对c-di-AMP调控作用的全面理解.同时,生物信息学分析发现在口腔常见细菌(如变异链球菌和牙龈卟啉单胞菌等)基因组中均存在编码c-di-AMP合成酶的基因,对于这一类基因的功能研究将为深入认识c-di-AMP信号系统在口腔细菌致病过程中的潜在作用提供重要线索,并为研究其在口腔细菌致病性中的调控机制开辟新天地.%Cyclic di-adenosine monophosphate(c-di-AMP) is a new signal nucleotide,widely distributed among bacteria and archaea,c-di-AMP plays an important role in the regulation of cell growth,cell wall homeostasis,interaction with host immune system and stress response.Bioinformatic analysis revealed that many oral bacterial genomes could encode the c-di-AMP synthase gene.Here we provide an overview of the synthesis and regulation of c-di-AMP in bacteria,highlighting the currently identified receptor proteins and pathways that are directly or indirectly controlled by c-di-AMP,as well as the recognition of c-di-AMP by the eukaryotic host.This review can serve as an important reference for future research of the c-di-AMP signaling system in oral bacteria.
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