Nickel-titanium(NiTi) rotary instruments are widely used because of their short preparation time and minimum procedural errors. However, NiTi instruments should form a contact with irrigating solutions during cleaning and sterilization; as a result, their mechanical properties are significantly affected. The effects of the fatigue resistance of NiTi instruments influenced by different solutions have been extensively investigated. This review introduces the mechanisms of contact of NiTi instruments with media. This review also describes experimental design results.%镍钛器械因其工作效率高、成形能力强而被广泛应用于临床。临床上，镍钛器械在根管冲洗和灭菌清洗过程中不可避免的与液体介质频繁接触，其力学性能可能会受到一定程度的影响。近年来，有不少学者研究了不同介质对镍钛器械疲劳抗性的影响。本文就镍钛器械与介质接触方式以及实验设计对实验结论的影响作一综述。
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