Bone tissue regeneration engineering involves supplying four basic elements required for bone formation to the defect site, namely, adequate blood supply, bone-forming cells, scaffolds or matrices and signaling molecules, such as growth factors. Platelet-derived growth factor(PDGF) has an important function in organogenesis, development, and trauma healing process, which depend on the binding of the protein tyrosine kinase receptors PDGF receptor-α and β.PDGF is a major mitogen for osteoblasts, fibroblasts, smooth muscle cells, and glial cells. Defects of Pdgf-related genes can lead to skeletal abnormalities, such as fusion of cervical vertebrae and ribs, as well as spina bifida. Following a fracture, platelets aggregate around the fracture site, which releases PDGF into the developing hematoma. in vitro studies have shown that PDGF promotes proliferation and osteogenicdifferentiation of mesenchymal stem cells, osteoblast migration, and fracture healing. Clinical studies show that PDGF can assist in extract socket and ridge augmentation regeneration, peri-implant soft tissue augmentation, and management of peri-implantitis. This paper reviews the effects of rhPDGF-BB on its structure and functions, experiment research in vivo and in vitro, and clinical trials.%组织再生需要生长因子及其类似物、成骨相关细胞、支架材料和良好的血供，其中血小板衍生生长因子（PDGF）是近年来研究和应用较多的一种生长因子，已获得其基因重组产品。PDGF通过激活PDGF受体（PDGFR）对细胞进行调节，现已确定PDGFR-α和PDGFR-β两种PDGFR。PDGF是成骨细胞、成纤维细胞、平滑肌细胞和神经胶质细胞等分裂增殖时重要的促细胞分裂原。小鼠Pdgf基因缺失会致其颈椎骨与肋骨融合或脊柱裂等骨骼畸形，骨折处大量血小板聚集并释放PDGF在内的多种生长因子。在小鼠骨折愈合过程中，PDGF对应的受体也有大量的表达。试验研究显示，PDGF-BB可刺激间质干细胞的增殖和分化，促进骨相关细胞迁移，促进骨组织愈合。临床研究显示，PDGF-BB可促进牙槽骨骨缺损修复，增高牙槽骨，促进种植体周围软组织愈合，治疗种植体周围炎。本文就PDGF-BB在口腔种植治疗中的应用从其结构与功能、试验研究和临床应用等研究进展作一综述。
展开▼
