Meckel's cartilage which is derived from the first branchial arch plays an important role during the development and growth of the mandible and also the morphology of malleus and incus. As a supporting bar for the mandibular early development, the intermediate region of Meckel's cartilage gradually degenerated after birth. This paper aimed to review the molecular mechanisms of the degeneration of Meckel's cartilage.%梅克尔软骨来源于第一鳃弓,在下颌骨的生长发育、锤骨和砧骨的形成中起重要作用.作为下颌骨早期发育的支架,梅克尔软骨在出生之后逐渐消亡.本文就梅克尔软骨消亡的分子机制作一综述.
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