目的：通过监测比较急性阑尾炎患者外周血脂氧素A4（LXA4）与降钙素元（PCT）水平，分析LXA4、PCT在急性阑尾炎患者的诊断中的作用及机制。方法：随机选取120例急性阑尾炎患者，均于手术前采用酶联免疫吸附法（ ELISA）检测患者外周血LXA4、PCT水平，并进行相关性分析。对照组选取同期健康体检者50例。结果：120例急性阑尾炎患者，结合手术或（和）病理诊断结果分为单纯性阑尾炎（35例）、化脓性阑尾炎（47例）、穿孔性阑尾炎（21例）、坏疽性阑尾炎（17例）。急性阑尾炎患者各组血清LXA4、PCT水平均显著高于对照组（ P﹤0.01）；化脓性阑尾炎组、穿孔性阑尾炎组及坏疽性阑尾炎组血清LXA4、PCT水平均显著高于单纯性阑尾炎组（ P﹤0.05）；坏疽性阑尾炎组及穿孔性阑尾炎组血清PCT水平高于化脓性阑尾炎组（ P﹤0.05）；急性阑尾炎患者血清LXA4与PCT水平呈显著正相关（ r＝-0.718，P＝0.002）。结论：在急性阑尾炎患者中血清LXA4与PCT的水平与患者的病情有较高的相关性，对急性阑尾炎的诊断、术前病情评估及是否手术均有一定的指导意义。%Objective Through the detection of the level of blood LXA4 and PCT in the Acute appendicitis patients to re-search the role and mechanism of LXA4 and PCT in the diagnosis of patients with acute appendicitis. Method 120 cases of pa-tients with acute appendicitis were randomly selected,the level of blood LXA4 and PCT were detected and analyzed before the surgery by using the method of enzyme-linked immunosorbent( ELISA). 50 cases of healthy check-up were selected as the control group. Results According to the surgery or( and)the pathological diagnosis,the cases of 120 patients with acute appendi-citis was divided into simple appendicitis(35 cases),suppurative appendicitis(47 cases),perforated appendicitis(21 cases) and gangrenous appendicitis(17 cases). The level of the serum of LXA4 and PCT in the groups of patients with acute appendici-tis were significantly higher than that of the control group(P﹤0. 01);The level of the serum of LXA4 and PCT in the groups of patients with Suppurative appendicitis,perforated appendicitis and gangrenous appendicitis were significantly higher than that of the simple appendicitis group( P﹤0. 05 );The level of the serum of PCT in the groups of patients with perforated appendicitis and gangrenous appendicitis were significantly higher than that of the suppurative appendicitis group( P﹤0. 05 );The serum of LXA4 in the acute appendicitis patients was significantly positively related to the serum of PCT( r =0. 718,P =0. 002 ) . Conclusion There is correlation between in the illness and the serum of LXA4 and PCT in the patients with acute appendicitis, and has certain guiding significance in the diagnosis,evaluations of the preoperative and whether surgery of acute appendicitis.
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