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《急性病杂志(英文版)》
>Memory enhancement by administration of ginger (Zingiber officinale) extract on morphine-induced memory impairment in male rats
Memory enhancement by administration of ginger (Zingiber officinale) extract on morphine-induced memory impairment in male rats
To study the chronic treatment with hydroethanolic extract of ginger(50,100 and200 mg/kg, p.o) would effect on the passive avoidance learning(PAL) and memory in rat.Methods:The rats were divided into eight groups.On the training trial, the mice received an electric shock when the animals were entered into the dark compartment.Twenty-four hours later,30 min after treatment, theSTL(step-through latency) andTDC(total time in dark compartments) was recorded and defined as the retention trial.Results:The time latency in morphine-treated group was lower than control(P<0.001).Treatment of the animals by100 and200 mg/kg of ginger extract before the training trial increased the time latency at24 hours after the training trial(P<0.01 andP<0.001). Administration of both100 and200 mg/kg doses of the extract in morphine received animal groups before retention trials also increased the time latency than the morphine-treated group groups(P<0.001).Conclusion:The results revealed that the ginger extract attenuated morphine-induced memory impairment.
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