生物重演律作为一个广泛传播的理论,在诸如动物分类学和发育生物学等生物进化研究上起着重要的指导作用.该理论指出:生物在个体发育过程中总是重演其所有祖先在进化过程中的每个发育阶段,即生物的个体发育过程重演其祖先的系统发生过程.换句话说,更高等有机体的继承和发展过程可从它的一些功能组织和器官中的祖细胞等.利用这个原理对微RNA(miRNA)的进化进行研究,是利用分子生物学方法,如多序列比对等,所没有采用过的.文中利用从人类特定的组织和器官收集到的微RNA表达数据为基础,从微RNA家族的角度进行整理并计算微RNA家族与组织的组织特异性,发现了某些特定组织和非组织特异性miRNA家族,并对这些数据进行了进化分析,最后在生物重演律下引用各具有组织特异性的微RNA家族所对应的组织在解剖学上的起源描述了微RNA家族整体的进化历史.%The recapitulation theory,as a widely disseminated theory,plays a very important role in macrobiology studies,such as taxonomy and evolutionary biology.This theory means that the ontogenetic processes of an organism are fast and simple systems developed from processes in progenitor organisms.In short,the higher organism inherits and develops process from its progenitors in some functional tissues and organs.The use of this theory in the study of miRNA evolution,using molecular methods such as multiple sequence alignment,has not been reported previously.In this article,we have taken an evolutionary analysis of miRNAs from the perspective of miRNA family expression data in human specific tissues and organs.We discovered certain tissue-specific and non-tissue-specific miRNA families,and these data were subjected to evolutionary analysis.At last,we described their overall evolutionary histories by referencing existing anatomical data on the occurrence and origins of specific organs under the recapitulation theory.
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