[Objective] The aim was to establish andida albicans vaginitis model of New Zealand white rabbits. [ Methods ] New Zealand white rabbits were divided into the hormone group (group A) and the control group (group B) ,then 2. 5 × 106/ ml,2.5 ×107/ml and 2.5 × 108/ml concentrations of Candida albicans liquid were added into the two groups, namely A1, A2, A3, B1, B2, B3, after that, set blank control group (group C),after vaccination,taking vaginal cleanness classification,vaginal lavage fluid fungal load and pathology organization watch as the indexes,the result of each model was evaluated. [Result] The best condition is hormone + made mode gas - bacilli concentration 2. 5 × 107/ml. [Conclusion] The result provide economic and applicable ideal animal model for the study of Candida albicans vaginitis.%[目的]建立新西兰大白兔的白色念珠菌性阴道炎模型.[方法]将新西兰大白兔均分为激素组(A组)和对照组(B组),2组再分别接种2.5×106/ml,2.5×107/ml,2.5×108/ml 3个浓度的白色念珠菌菌液,即A1、A2、A3、B1、B2、B36组,另设空白对照组(C组),接种后以阴道分泌物清洁度分级、阴道灌洗液的真菌载量和病理组织观察为指标,评价各组模型的建立结果.[结果]最佳的造模条件是激素+菌液浓度2.5×107/ml.[结论]结果为白色念珠菌性阴道炎的研究提供了经济实用的理想动物模型.
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