[Objective] To study the effect of dry methods on the content of butylphthalide in Ligusticum chuanxiong Hort. Stems and leaves (Miwu). [Methods] The content of butylphthalide in Miwu from different dry methods was determinated by HPLC. [Results] There was a good linear relationship between butylphthalide concentration and peak area when the sample injection was from 0. 123 1 to 1.2310 μg/ml ( R = 0.9999), the quantification limit was 0.012 31 mg/ml, the average recovery was 100. 1% , and RSD was 0.93% (n=9). Different dry methods had some influence on the butylphthalide content in Miwu. The content of butylphthalide was 0. 024 84% , 0. 051 78% and 0.064 68% in tested samples of Miwu that were respectively obtained by sun-drying, shade drying and oven-drying after sunshine. As to Miwu, oven-drying after sunshine was superior to the above two methods. [ Conclusions] Among the three drying methods, oven-drying after sunshine was the optimal one for Miwu.%[目的]研究干燥方法对蘼芜中丁基苯酞含量的影响.[方法]采用高效液相色谱法测定不同干燥方法干燥的蘼芜中丁基苯酞的含量.[结果]在0.1231 ～1.2310 μ.g/ml范围内,丁基苯酞浓度与峰面积呈良好的线性关系(R =0.9999),定量限为0.01231 mg/ml,平均回收率为100.1％,RSD为0.93％(n=9).自然晒干、自然阴干和晒后烘干3种干燥方法干燥的蘼芜中丁基苯酞的含量分别为0.02484％、0.05178％和0.06468％.其中以晒后烘干处理的含量最高,自然晒干处理的含量最低.[结论]蘼芜的干燥方法宜选用晒后烘干法.
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