[目的]评价卷丹的安全性,为其综合利用提供依据.[方法]通过急性毒性试验测定南通军山卷丹水提物的急性毒性及可能的中毒症状,并测定小鼠的最大耐受量.通过小鼠骨髓微核试验对其进行系统安全性评价.[结果]卷丹对小鼠的半数致死剂量(LD)大于80 g/kg,并且小鼠骨髓微核试验结果为阴性.[结论]卷丹无明显急性毒性反应,无遗传毒性,是一种安全无毒的中药,可开发成中药新药.%[Objective] The research aimed to evaluate the safety of Lilium lancifolium Thunb. and provide basis for its comprehensive utilization. [ Method ] Through acute toxicity experiment, the acute toxieity and possible poisoning symptoms of water extracts from L. lancifolium in the areas of Junshan Hill in Nantong were measured and the maximum tolerance dose of mice was measured. Its systematic safety was evaluated by mice bone marrow mieronucleus test.[Result] LD50 of L. lancifolium to mice was more than 80 g/kg. The mice bone marrow micronucleus test showed negative results. [Conclusion ] It was found that L. lancifolium had no obvious acute toxicity reaction and genetic toxicity. It is a kind of safe and nontoxic Chinese herb and it can be developed as a new kind of Chinese herb.
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