Bovine brucellosis is one of the most important zoonotie diseases worldwide, and is widely spread in developing countries. The disease, which results in serious economic losses due to late term abortion, stillborn and weakly calves, is caused by Gram negative coccobacilli bacteria of the genus Brucella. Lesions consist of necrotic placentitis and interstitial mastitis in pregnant cows, and fibrinous pleurifis with interstitial pneumonia in aborted fetuses and newborn calves. The pathogenesis of Brucella abortus and the ability of the pathogen to invade phagocytic and nonphagocytic host cells, resist the acidified intraphagosomal environment, and inhibit phagosome - lysosome fusion were expounded.Significant aspects of innate and adaptive immunity against brucellosis were also discussed.%牛布鲁氏菌病是一种非常重要的世界流行的动物传染病.在发展中国家流行范围广,经济损失严重.该病的病原是一种革兰氏阴性球杆菌,能够引起怀孕母牛胎盘坏死及间质性乳腺炎,新生小牛多患有纤维素性肺炎.就流产布鲁氏菌的致病性、时吞噬细胞和非吞噬细胞的侵袭力、在胞内的生存机制及阻碍吞噬细小体-溶酶体的粘附进行综述,尤其对获得性免疫反应如何抵抗布鲁氏菌感染作了重要的阐述.
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