Epidermal stem cells (ESCs) are mainly located in basal layer and the bulge of the outer root sheath, characterized by non-differentiation , multiplying and self-renewing abilities. Isolation and culture epidermal stem cells in vitro, cultivating skin organ sample and using tissue engineering method to study the proliferation and differentiation , Though adding to our understanding of ESCs biology characteristics, this paper provides an overview of molecular mechanism on regulatingthe proliferation and differentiation of ESCs in recent years.%表皮干细胞(Epidermal stem cells,ESCs)主要是位于表皮基底层及毛囊外根鞘隆突部,具有自我更新和增殖分化能力的细胞.通过体外分离表皮干细胞、培养皮肤器官样组织和利用细胞工程等方法研究ESCs的增殖、分化调控过程,加深了对ESCs生物学特征的了解.就近几年来ESCs分化调控机制进行了综述.
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