Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

Samuel M.Waititu; Fugui Yin; Rob Patterson; Juan C.Rodriguez-Lecompte; Charles M.Nyachoti

首页> 中文期刊> 《畜牧与生物技术杂志：英文版》 >Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

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Background: This study investigated the response of piglets receiving a yeast extract without or with a multi-enzyme mixture compared with an antimicrobial growth promoter(AGP) on performance, immune status and gut structure after an E. coli lipopolysaccharide(LPS) challenge. Thirty-six pigs were allotted to six treatments including: a non-challenged control(NCC); LPS-challenged control(CC); CC + AGP; CC + yeast extract; CC + enzymes; and CC + enzymes + yeast extract. On d 7, pigs were bled and thereafter injected with LPS or sterile saline. Blood samples were collected at 6, 48, and 96 h post-challenge. After 96 h post-challenge, pigs were euthanized to obtain duodenal, jejunal and ileal samples.Results: Overall(d 1 to 11), compared with CC pigs, AGP attenuated the LPS-induced reduction in ADG(P = 0.004),ADFI(P = 0.03) and gain/feed ratio(P = 0.01). At 6 h post-challenge, AGP pigs had lower plasma urea N(PUN; P = 0.02)and serum TNF-α concentration(P = 0.07), and higher platelet count(P = 0.04) and serum IL-10 concentration(P = 0.02) than CC pigs. At 48 h post-challenge, AGP pigs had lower PUN(P = 0.02) than CC pigs, whereas enzymes + yeast extract interacted non-additively(P = 0.001) to reduce PUN. At 96 h post-challenge, AGP pigs had lower PUN(P = 0.02)and higher duodenal(P = 0.03), jejunal(P = 0.01) and ileal(P = 0.07) villus height than CC pigs. In addition, enzymes +yeast extract interacted additively and non-additively to reduce ileal IFN-γ(P 0.10) were observed between AGP and enzymes + yeast extract pigs on other measured parameters except for the downregulation of ileal IFN-γ(P < 0.0001) and TNF-α(P = 0.003) in enzymes + yeast extract pigs at 96 h post-challenge.Conclusions: The LPS challenged piglets receiving enzymes + yeast extract showed beneficial responses in gut structure and immunity commensurate with those receiving antibiotics, though the latter had better overall growth performance.

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《畜牧与生物技术杂志：英文版》 |2017年第002期|P.378-390|共13页
作者
Samuel M.Waititu; Fugui Yin; Rob Patterson; Juan C.Rodriguez-Lecompte; Charles M.Nyachoti;
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[1]Department of Animal Science, University of Manitoba,201-12 Dafoe Road,Winnipeg, M6 R3T 2N2, Canada. [2]Canadian Bio-systems Inc.,Calgary, AB T2C OJT, Canada. [3]Atlantic Veterinary College, University of Prince Edward Island,Charlottetown, PE C1A 4P3, Canada.;

[1]Department of Animal Science, University of Manitoba,201-12 Dafoe Road,Winnipeg, M6 R3T 2N2, Canada. [2]Canadian Bio-systems Inc.,Calgary, AB T2C OJT, Canada. [3]Atlantic Veterinary College, University of Prince Edward Island,Charlottetown, PE C1A 4P3, Canada.;

[1]Department of Animal Science, University of Manitoba,201-12 Dafoe Road,Winnipeg, M6 R3T 2N2, Canada. [2]Canadian Bio-systems Inc.,Calgary, AB T2C OJT, Canada. [3]Atlantic Veterinary College, University of Prince Edward Island,Charlottetown, PE C1A 4P3, Canada.;

[1]Department of Animal Science, University of Manitoba,201-12 Dafoe Road,Winnipeg, M6 R3T 2N2, Canada. [2]Canadian Bio-systems Inc.,Calgary, AB T2C OJT, Canada. [3]Atlantic Veterinary College, University of Prince Edward Island,Charlottetown, PE C1A 4P3, Canada.;

[1]Department of Animal Science, University of Manitoba,201-12 Dafoe Road,Winnipeg, M6 R3T 2N2, Canada. [2]Canadian Bio-systems Inc.,Calgary, AB T2C OJT, Canada. [3]Atlantic Veterinary College, University of Prince Edward Island,Charlottetown, PE C1A 4P3, Canada.;

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原文格式 PDF
正文语种 CHI
中图分类饲料添加剂;
关键词
饲用酶制剂断奶仔猪肠道结构免疫状态生长性能短期影响酵母抽提物酵母提取物;

机译：饲用酶制剂断奶仔猪肠道结构免疫状态生长性能短期影响酵母抽提物酵母提取物;

Short-term effect of supplemental yeast extract without or with feed enzymes on growth performance, immune status and gut structure of weaned pigs challenged with Escherichia coli lipopolysaccharide

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