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首页> 外文期刊>畜牧与生物技术杂志(英文版) >Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringensinduced necrotic enteritis
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Effects of Bacillus coagulans supplementation on the growth performance and gut health of broiler chickens with Clostridium perfringensinduced necrotic enteritis

机译：凝结芽孢杆菌补充剂对产气荚膜梭状芽胞杆菌引起的坏死性肠炎肉鸡生长性能和肠道健康的影响

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摘要

Background: The poultry industry is in need of effective antibiotic alternatives to control outbreaks of necrotic enteritis (NE) due to Clostridium perfringens. Methods: This study was conducted to investigate the effects of feeding Bacillus coagulans on the growth performance and gut health of broiler chickens with C. perfringens-induced NE. Two hundred and forty 1-day-old broiler chicks were randomly assigned to a 2 × 2 factorial arrangement with two dietary B. coagulans levels (0 or 4 × 109 CFU/kg of diet) and two disease challenge statuses (control or NE challenged).Results: NE-induced reduction in body weight gain was relieved by the addition of B. coagulans into broiler diets compared with the NE-infected birds. NE infection damaged intestinal morphological structure, promoted intestinal C. perfringens growth and liver invasion, and enhanced anti-C. perfringens specific sIgA concentrations in the gut and specific IgG levels in serum compared with the uninfected birds. NE infection significantly (P < 0. 05) decreased mucin-2 (at 14 d post-infection (DPI), toll -like receptor 2 (TLR2, at 7 and 14 DPI), TLR4 (at 7 and 14 DPI), tumor necrosis factor super family 15 (TNFSF15, at 7 and 14 DPI), lysozyme (LYZ, at 14 DPI) and fowlicidin-2 (at 7 and 14 DPI) mRNA levels, whereas it dramatically (P = 0. 001) increased IFN-γ mRNA levels at 7 DPI. However, challenged birds fed diets supplemented with B. coagulans showed a significant (P < 0. 01) decrease in gut lesion scores, decreased C. perfringens numbers in the cecum and liver, and an increase in fowlicidin-2 mRNA levels in compared with the uninfected birds. In addition, compared with the non-supplemented group, dietary inclusion of B. coagulans improved intestinal barrier structure, further increased specific sIgA levels and alkaline phosphatase (IAP) activity in the jejunum, enhanced the expression of jejunum lysozyme mRNA, and inhibited the growth, colonization, and invasion of C. perfringens; in contrast, it reduced serum-specific IgG concentrations and jejunum IFN-γ mRNA levels.Conclusion: These results indicated that dietary B. coagulans supplementation appeared to be effective in preventing the occurrence and reducing the severity of C. perfringens-induced NE in broiler chickens.
机译：背景：家禽行业需要有效的抗生素替代品来控制由产气荚膜梭菌引起的坏死性肠炎（NE）的爆发。方法：本研究旨在研究凝结芽孢杆菌对产气荚膜梭菌诱导的NE对肉仔鸡生长性能和肠道健康的影响。将240只1日龄的肉鸡随机分配至2×2因子安排，其中两种膳食凝结芽孢杆菌水平（0或4×109 CFU / kg日粮）和两种疾病挑战状态（对照或NE挑战） ）。结果：与NE感染的禽类相比，在肉鸡日粮中添加凝结芽孢杆菌可减轻NE引起的体重减轻。 NE感染破坏了肠道的形态结构，促进了产气荚膜梭菌的生长和肝脏侵袭，并增强了抗C的能力。与未感染的禽类相比，肠道中的产气荚膜特异性sIgA浓度和血清中特异性IgG水平升高。 NE感染显着（P <0. 05）降低mucin-2（在感染后14 d（DPI），toll​​样受体2（TLR2在7和14 DPI），TLR4（在7和14 DPI），肿瘤减少坏死因子超家族15（TNFSF15，在7和14 DPI时），溶菌酶（LYZ，在14 DPI时）和fowlicidin-2（在7和14 DPI时）mRNA水平，而其显着（P = 0. 001）增加了IFN-在7 DPI时γmRNA水平;但是，饲喂补充凝结芽孢杆菌的挑战鸟的肠道病变评分显着降低（P <0. 01），盲肠和肝脏的产气荚膜梭菌数量减少，而Fowlicidin升高与未感染禽类相比，-2 mRNA的水平;此外，与未补充禽类相比，日粮中添加凝结芽孢杆菌可改善肠道屏障结构，空肠中的特异性sIgA水平和碱性磷酸酶（IAP）活性进一步提高，空肠溶菌酶mRNA的表达，并抑制产气荚膜梭菌的生长，定植和入侵;相反结论：这些结果表明，日粮中添加凝结芽孢杆菌似乎可以有效防止产气荚膜梭菌诱导的NE在肉鸡中的发生并降低其严重程度。 。

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  • 来源
    《畜牧与生物技术杂志(英文版)》 |2018年第2期|407-420|共14页
  • 作者

    Yuanyuan Wu; Yujing Shao; Bochen Song; Wenrui Zhen; Zhong Wang; Yuming Guo; Muhammad Suhaib Shahid; Wei Nie;

  • 作者单位

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

    College of Biology, China Agricultural University, Beijing, China;

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

    State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China;

  • 收录信息 中国科学引文数据库(CSCD);
  • 原文格式 PDF
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