Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis

Heju Zhong; Li Tang; Gang Tian; Daiwen Chen; De Wu; Zhengfeng Fang; Hao Li; Guangmang Liu; Haifeng Wan; Yves Mercier; Xiaoling Zhang; Yan Lin; Lianqiang Che; Shengyu Xu

首页> 外文期刊>畜牧与生物技术杂志(英文版) >Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis

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Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis

机译：甲硫氨酸的羟基类似物可增加母亲对甲硫氨酸的消耗，而不会损害母亲的能量稳态

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Background:To determine responses of neonatal intestine to maternal increased consumption of DL-methionine (DLM) or DL-2-hydroxy-4-methylthiobutanoic acid (HMTBA),eighteen primiparous sows (Landrace × Yorkshire) were allocated based on body weight and backfat thickness to the control,DLM and HMTBA groups (n =6),with the nutritional treatments introduced from postpartum d0 to d14.Results:The DLM-fed sows showed negative energy balance manifested by lost bodyweight,lower plasma glucose,subdued tricarboxylic acid cycle,and increased plasma lipid metabolites levels.Both villus height and ratio of villus height to crypt depth averaged across the small intestine of piglets were higher in the DLM and HMTBA groups than in the control group.Piglet jejunal oxidized glutathione concentration and ratio of oxidized to reduced glutathione were lower in the HMTBA group than in the DLM and control groups.However,piglet jejunal aminopeptidase A,carnitine transporter 2 and IGF-Ⅱ precursor mRNA abundances were higher in the DLM group than in the HMTBA and control groups.Conclusion:Increasing maternal consumption of methionine as DLM and HMTBA promoted neonatal intestinal growth by increasing morphological development or up-regulating expression of genes responsible for nutrient metabolism.And increasing maternal consumption of HMTBA promoted neonatal intestinal antioxidant capacity without compromising maternal energy homeostasis during early lactation.

机译：背景：为了确定新生儿肠道对孕妇增加DL-蛋氨酸（DLM）或DL-2-羟基-4-甲基硫代丁酸（HMTBA）摄入的反应，根据体重和背脂分配了18头初产母猪（Landrace×Yorkshire） DLM和HMTBA组（n = 6）的对照组厚度增加，从产后d0到d14进行营养治疗。结果：DLM喂养的母猪表现出负能量平衡，表现为体重下降，血浆葡萄糖降低，三羧酸循环减弱在DLM和HMTBA组中，仔猪小肠的绒毛高度和绒毛高度与隐窝深度的比率均比对照组高。仔猪空肠氧化谷胱甘肽浓度和氧化谷胱甘肽比率HMTBA组的谷胱甘肽减少量低于DLM组和对照组。但是，仔猪空肠氨肽酶A，肉碱转运蛋白2和IGF-Ⅱ前体mRNA丰度结论：DLM和HMTBA通过增加形态发育或上调负责营养代谢的基因表达来促进新生儿肠道生长，从而增加了母亲的蛋氨酸摄入量，从而增加了母亲的蛋氨酸含量。在哺乳初期，HMTBA的使用可提高新生儿的肠道抗氧化能力，而不会损害母体能量的体内平衡。

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《畜牧与生物技术杂志(英文版)》 |2017年第1期|182-195|共14页
作者
Heju Zhong; Li Tang; Gang Tian; Daiwen Chen; De Wu; Zhengfeng Fang; Hao Li; Guangmang Liu; Haifeng Wan; Yves Mercier; Xiaoling Zhang; Yan Lin; Lianqiang Che; Shengyu Xu;
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Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Adisseo France S.A.S., CERN, Commentry, France;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

Key Laboratory for Animal Disease Resistance Nutrition of the Ministry of Education, Animal Nutrition Institute, Sichuan Agricultural University, Ya'an 625014, China;

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Increased maternal consumption of methionine as its hydroxyl analog promoted neonatal intestinal growth without compromising maternal energy homeostasis

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