Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals

Abdollah Akbarian; Joris Michiels; Jeroen Degroote; Maryam Majdeddin; Abolghasem Golian; Stefaan De Smet

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Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals

机译：家禽热应激和氧化应激之间的关联;线粒体功能障碍和饮食干预与植物化学物质

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Heat as a stressor of poultry has been studied extensively for many decades;it affects poultry production on a worldwide basis and has significant impact on well-being and production.More recently,the involvement of heat stress in inducing oxidative stress has received much interest.Oxidative stress is defined as the presence of reactive species in excess of the available antioxidant capacity of animal cells.Reactive species can modify several biologically cellular macromolecules and can interfere with cell signaling pathways.Furthermore,during the last decade,there has been an ever-increasing interest in the use of a wide array of natural feed-delivered phytochemicals that have potential antioxidant properties for poultry.In light of this,the current review aims to (1) summarize the mechanisms through which heat stress triggers excessive superoxide radical production in the mitochondrion and progresses into oxidative stress,(2) illustrate that this pathophysiology is dependent on the intensity and duration of heat stress,(3) present different nutritional strategies for mitigation of mitochondrial dysfunction,with particular focus on antioxidant phytochemicals.Oxidative stress that occurs with heat exposure can be manifest in all parts of the body;however,mitochondrial dysfunction underlies oxidative stress.In the initial phase of acute heat stress,mitochondrial substrate oxidation and electron transport chain activity are increased resulting in excessive superoxide production.During the later stage of acute heat stress,down-regulation of avian uncoupling protein worsens the oxidative stress situation causing mitochondrial dysfunction and tissue damage.Typically,antioxidant enzyme activities are upregulated.Chronic heat stress,however,leads to downsizing of mitochondrial metabolic oxidative capacity,up-regulation of avian uncoupling protein,a clear alteration in the pattern of antioxidant enzyme activities,and depletion of antioxidant reserves.Some phytochemicals,such as various types of flavonoids and related compounds,were shown to be beneficial in chronic heat-stressed poultry,but were less or not effective in non-heat-stressed counterparts.This supports the contention that antioxidant phytochemicals have potential under challenging conditions.Though substantial progress has been made in our understanding of the association between heat stress and oxidative stress,the means by which phytochemicals can alleviate oxidative stress have been sparsely explored.

机译：作为家禽应激源的热已被广泛研究了数十年;它在全球范围内影响着家禽生产，并对人们的福祉和生产产生重大影响。最近，热应激在诱导氧化应激中的作用引起了广泛关注。氧化应激被定义为存在超过动物细胞可用抗氧化能力的反应性物种。反应性物种可以修饰几种生物细胞大分子并可以干扰细胞信号传导途径。此外，在过去的十年中，有鉴于此，人们越来越关注使用多种天然饲料输送的植物化学物质，这些化学物质对禽类具有潜在的抗氧化特性。鉴于此，本综述旨在（1）总结热应激触发动物体内过氧化物自由基产生过多的机制。线粒体并发展为氧化应激，（2）说明这种病理生理依赖于强度和持续热应激的持续时间，（3）提出了减轻线粒体功能障碍的不同营养策略，尤其是抗氧化剂植物化学物质。暴露于热的氧化应激可以在身体的所有部位显现出来;但是，线粒体功能异常是氧化的基础在急性热应激的初始阶段，线粒体底物的氧化和电子传递链的活性增加，导致过量的超氧化物产生。功能障碍和组织损伤。通常，抗氧化酶的活性上调。但是，慢性热应激会导致线粒体代谢氧化能力的降低，禽类解偶联蛋白的上调，抗氧化酶活性的模式发生明显改变以及耗竭。抗氧化剂储备。一些植物化学物质，苏作为多种类黄酮和相关化合物，已显示出对慢性热应激家禽有益，但对非热应激家禽则无效或无效。这支持了抗氧化剂植物化学物质在挑战性条件下具有潜力的论点。在我们对热应激和氧化应激之间关系的理解上取得了实质性的进展，稀疏地探索了植物化学物质减轻氧化应激的方法。

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《畜牧与生物技术杂志(英文版)》 |2017年第1期|1-14|共14页
作者
Abdollah Akbarian; Joris Michiels; Jeroen Degroote; Maryam Majdeddin; Abolghasem Golian; Stefaan De Smet;
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Department of Animal Production, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Proefhoevestraat 10, Melle 9090,Belgium;

Centre of Excellence in the Animal Science Department, Ferdowsi University of Mashhad, P.O.Box: 91775-1163, Mashhad, Iran;

Department of Applied Biosciences, Ghent University, Valentin Vaerwyckweg 1, Ghent 9000,Belgium;

Department of Applied Biosciences, Ghent University, Valentin Vaerwyckweg 1, Ghent 9000,Belgium;

Department of Animal Production, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Proefhoevestraat 10, Melle 9090,Belgium;

Centre of Excellence in the Animal Science Department, Ferdowsi University of Mashhad, P.O.Box: 91775-1163, Mashhad, Iran;

Department of Applied Biosciences, Ghent University, Valentin Vaerwyckweg 1, Ghent 9000,Belgium;

Centre of Excellence in the Animal Science Department, Ferdowsi University of Mashhad, P.O.Box: 91775-1163, Mashhad, Iran;

Department of Animal Production, Laboratory for Animal Nutrition and Animal Product Quality, Ghent University, Proefhoevestraat 10, Melle 9090,Belgium;

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Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals

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