Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E.coli

Jae Cheol Kim; Bruce P.Mullan; John L.Black; Robert J.E.Hewitt; Robert J.van Barneveld; John R.Pluske

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Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E.coli

机译：补充乙酰水杨酸可提高蛋白质利用效率，而补充维生素E可以减少断肠仔猪对肠毒素致病性大肠杆菌的炎症反应

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Background:This experiment was conducted to test the hypothesis that vitamin E (Vit E) and acetylsalicylic acid (ASA),a cyclooxygenase-2 (COX-2) inhibitor,will additively reduce the production of the immunosuppressive molecule prostaglandin E2 (PGE2) and hence reduce inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E.coli.Methods:The experiment was conducted in a research facility with 192 individually-housed male weaner pigs (Landrace × Large White) weighing 6.6 ± 0.04 kg (mean ± SEM).The pigs were experimentally infected with an enterotoxigenic strain of E.coli and were allocated to a 2 × 3 factorial design with the respective factors being without and with 125 ppm ASA and three levels ofVit E supplementation (50,100 or 200 IU/kg diet,dl-α-tocopheryl acetate).Results:Acetylsalicylic acid supplementation improved average daily gain (P ＜ 0.05) and tended to improve feed:gain ratio (P ＜ 0.10) during the first 14 d after weaning.Acetylsalicylic acid supplementation also improved (P ＜ 0.001) amino acid utilization efficiency (as assessed by plasma urea level) and tended to decrease (P ＜ 0.10) PGE2 production in the liver without affecting small intestinal histology and tight junction protein mRNA expression in the jejunal epithelium.Vitamin E supplementation greater than 100 IU/kg diet sustained both the plasma Vit E concentration (P ＜ 0.001) and plasma haptoglobin content (P ＜ 0.001) after weaning.However,there was no additive effects of the combined supplementation of ASA and Vit E on performance,intestinal barrier function and inflammatory responses of weaned pigs.Conclusions:Although ASA and vitamin E improved amino acid utilization efficiency and reduced acute inflammatory responses,ASA and vitamin E did not additively reduce production of PGE2 and inflammatory responses in weaner pigs experimentally infected with an enterotoxigenic strain of E.coli.

机译：背景：本实验旨在验证以下假设，即维生素E（Vit E）和环氧化酶2（COX-2）抑制剂乙酰水杨酸（ASA）会额外减少免疫抑制分子前列腺素E2（PGE2）和方法：本实验是在一个研究设施中对192头独立饲养的雄性断奶仔猪（Landrace×Large White）进行试验，体重为6.6±0.04 kg（平均值± SEM）。用实验方法将猪感染肠毒素的大肠杆菌，并按照2×3因子设计进行分配，分别采用无和125 ppm ASA以及三种水平的Vit E补充（50,100或200 IU / kg）结果：断奶后头14 d，补充乙酰水杨酸可改善平均日增重（P ＜0.05），并有提高饲料/增重比（P ＜0.10）的趋势。补充柠檬酸还可以提高（P ＜0.001）氨基酸利用效率（通过血浆尿素水平评估），并倾向于降低（P ＜0.10）肝脏中PGE2的产生，而不会影响空肠的小肠组织学和紧密连接蛋白mRNA表达断奶后补充维生素E大于100 IU / kg的饮食可使血浆Vit E浓度（P ＜0.001）和血浆触觉珠蛋白含量（P ＜0.001）均维持不变。结论：尽管ASA和维生素E提高了氨基酸利用效率并减少了急性炎症反应，但是ASA和维生素E并没有降低断奶仔猪的PGE2产生和炎症反应实验上感染了大肠杆菌的产肠毒素菌株。

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《畜牧与生物技术杂志(英文版)》 |2017年第1期|143-153|共11页
作者
Jae Cheol Kim; Bruce P.Mullan; John L.Black; Robert J.E.Hewitt; Robert J.van Barneveld; John R.Pluske;
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School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia;

AB Vista Asia Pte.Ltd., Balestier Road, The Mezzo, 329682 Singapore,Singapore;

Department of Agriculture and Food, Pork Innovation, South Perth, WA 6151, Australia;

John L Black Consulting, Warrimoo, NSW 2774, Australia;

SunPork Farms Solutions, Loganholme, QLD 4129, Australia;

Barneveld Nutrition Pry Ltd, Loganholme, QLD 4129, Australia;

School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia;

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Acetylsalicylic acid supplementation improves protein utilization efficiency while vitamin E supplementation reduces markers of the inflammatory response in weaned pigs challenged with enterotoxigenic E.coli

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