Dietary stimulation of the endogenous somatotropic axis in weaner and grower-finisher pigs using medium chain triglycerides and cysteamine hydrochloride

David W.Miller; Zoe Prosser; Edward Y.W.Chee; Christian F.Hansen; Frank R.Dunshea; Bruce P.Mullan; John R.Pluske

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Dietary stimulation of the endogenous somatotropic axis in weaner and grower-finisher pigs using medium chain triglycerides and cysteamine hydrochloride

机译：使用中链甘油三酸酯和半胱胺盐酸盐对断奶仔猪和成年肥育猪的内源性生长轴进行饮食刺激

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Background:Three experiments were conducted to examine the overall hypothesis that addition of medium chain triglycerides (MCT) and cysteamine hydrochloride (CSH) into the diets of young and growing pigs would stimulate the endogenous somatotropic axis to improve growth and performance.Results:In Experiment 1,weaner pigs were given either a 5 d dietary supplement of 5 ％ MCT (n =8) or a control diet (n =8).MCT increased the plasma concentration of growth hormone (GH;P ＜ 0.05) and the GH secretagogue,ghrelin (P ＜ 0.05).Additionally,the MCT treatment reduced scouring (P ＜ 0.05),maintained villous height in the small intestine (P ＜ 0.05) and stabilised daily weight gain (P ＜ 0.05),compared to the controls.Experiment 2 compared the effects of 4 levels (0,1,3 and 6 ％ v/v) of MCT supplementation in grower-finisher male pigs,of approximately 35 kg live weight (n =15 per treatment).Blood samples taken after 7 wk of treatment showed that the MCT supplementation increased circulating ghrelin (P ＜ 0.001),GH (P ＜ 0.01) and insulin (P ＜ 0.05) concentrations in a dose-dependent manner.Daily weight gain,feed intake and feed conversion ratio were not affected by the MCT diets.In Experiment 3,64 female pigs of approximately 60 kg live weight were allocated to one of three dietary treatments:control (n =20);6 ％ MCT (n =21);and 70 mg/kg CSH (n =21).After 3 wk of supplementation,the MCT treated pigs had a higher plasma concentration of ghrelin compared to the control and CSH pigs (P ＜ 0.05).Plasma concentrations of GH and weight were not affected by any of the dietary treatments.Conclusions:Evidence is provided in Experiment 1 to support the use of dietary MCT supplements,perhaps acting via stimulation of somatotropic endocrine pathways,to minimise weaning-associated disorders such as slowing of growth and diarrhoea.In Experiments 2 and 3,although there was no effect on weight gain or feed conversion ratio in either experiment,MCT and CSH increased endocrine components of the somatotropic axis.

机译：背景：进行了三个实验以检验总体假设，即在成年和成年猪的日粮中添加中链甘油三酸酯（MCT）和半胱胺盐酸盐（CSH）会刺激内源性生长激素来改善生长和性能。 1，给断奶仔猪5d饲喂5％MCT（n = 8）或对照日粮（n = 8）。MCT增加生长激素的血浆浓度（GH; P ＜0.05）和GH促分泌素胃饥饿素（P ＜0.05）。此外，MCT处理可减少煮沸（P ＜0.05），维持小肠绒毛高度（P ＜0.05），稳定日增重（P ＜0.05），与对照组相比。图2比较了在生长肥育型雄性猪中添加4种水平（0、1、3和6％v / v）对体重约35千克活重（每处理n = 15）的成年雄性猪的效果。7周后采血的治疗表明，MCT补充剂可增加循环生长激素释放肽（P ＜ 0.001），GH（P ＜0.01）和胰岛素（P ＜0.05）浓度呈剂量依赖性。MCT日粮不影响日增重，采食量和饲料转化率。实验3,64只雌性猪将约60公斤活重分配给三种饮食疗法之一：对照（n = 20）; 6％MCT（n = 21）; 70 mg / kg CSH（n = 21）。补充3周后，MCT处理的猪的生长素释放肽的血浆浓度高于对照组和CSH的猪（P ＜0.05）。GH的血浆浓度和体重不受任何饮食处理的影响。结论：实验1提供了证据来支持使用饮食中的MCT补品可能通过刺激生长激素的内分泌途径起作用，以最大程度地减少与断奶相关的疾病，例如生长和腹泻的减慢。在实验2和3中，尽管在任何一个实验中对体重增加或饲料转化率都没有影响， MCT和CSH增加了促生长素的内分泌成分ic轴。

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《畜牧与生物技术杂志(英文版)》 |2017年第2期|405-416|共12页
作者
David W.Miller; Zoe Prosser; Edward Y.W.Chee; Christian F.Hansen; Frank R.Dunshea; Bruce P.Mullan; John R.Pluske;
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School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia;

School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia;

School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia;

Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Groennegaardsvej 2, 1870 Frederiksberg C, Denmark;

Melbourne School of Land and Environment, University of Melbourne, Parkville, VIC 3051, Australia;

Department of Agriculture and Food Western Australia, Bentley Delivery Center, Locked Bag 4, Bentley, WA 6983, Australia;

School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150, Australia;

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Dietary stimulation of the endogenous somatotropic axis in weaner and grower-finisher pigs using medium chain triglycerides and cysteamine hydrochloride

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