Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed sheep

Xiaoyong Chen; Dan Wang; Hai Xiang; Weitao Dun; Dave O.H.Brahi; Tao Yin; Xingbo Zhao

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Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed sheep

机译：tRNA-Lys基因中的线粒体DNA T7719G影响小尾羊的产仔量

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Background:In farm animals,mitochondrial DNA (mtDNA) effect on economic performance remains hot-topic for breeding and genetic selection.Here,53 maternal lineages of Small-tailed Han sheep were used to investigate the association of mitochondrial DNA variations and the lambing litter size.Results:Sequence sweeping of the mitochondrial coding regions discovered 31 non-synonymous mutations,and the association study revealed that T7719G in mtDNA tRNA-Lys gene was associated with litter size (P ＜ 0.05),manifesting 0.29 lambs per litter between the G and T carriers.Furthermore,using the mixed linear model,we assayed the potential association of the ovine litter size and haplogroups and multiple-level mtDNA haplotypes,including general haplotypes,assembled haplotypes of electron transport chain contained sequences (H-ETC),mitochondrial respiratory complex contained sequences (H-MRC) and mitochondrial genes (H-gene,including polypeptide-coding genes,rRNA genes and tRNA genes).The strategy for assembled mitochondrial haplotypes was proposed for the first time in mtDNA association analyses on economic traits,although none of the significant relations could be concluded (P ＞ 0.05).In addition,the nuclear major gene BMPR1B was significantly correlated with litter size in the flock (P＜ 0.05),however,did not interact with mtDNA T7719G mutation (P＞ 0.05).Conclusions:Our results highlight mutations of ovine mitochondrial coding genes,suggesting T7719G in tRNA-Lys gene be a potentially useful marker for selection of sheep litter size.

机译：背景：在农场动物中，线粒体DNA（mtDNA）对经济表现的影响仍然是繁殖和遗传选择的热点。在这里，使用53尾小尾寒羊的母系谱系来研究线粒体DNA变异与羔羊窝的关联。结果：线粒体编码区的序列扫描发现了31个非同义突变，关联研究表明，mtDNA tRNA-Lys基因中的T7719G与窝产仔数相关（P ＜0.05），每窝产仔数为0.29只。此外，使用混合线性模型，我们分析了绵羊凋落物大小和单倍群与多水平mtDNA单倍型的潜在关联，包括一般单倍型，电子传输链包含序列的组装单倍型（H-ETC），线粒体呼吸道复合物包含序列（H-MRC）和线粒体基因（H基因，包括多肽编码基因，rRNA基因和tRNA基因）。 mtDNA关联分析首次提出了组装线粒体单倍型的经济性状，尽管没有明显的相关性（P＞ 0.05）。此外，核主要基因BMPR1B与家禽产仔数显着相关（ P ＜0.05），但与mtDNA T7719G突变无相互作用（P＞ 0.05）。。

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《畜牧与生物技术杂志(英文版)》 |2017年第3期|568-573|共6页
作者
Xiaoyong Chen; Dan Wang; Hai Xiang; Weitao Dun; Dave O.H.Brahi; Tao Yin; Xingbo Zhao;
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College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;

Institute of Animal Science and Veterinary of Hebei Province,Baoding 071000,China;

College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;

College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;

Institute of Animal Science and Veterinary of Hebei Province,Baoding 071000,China;

College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;

College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;

College of Animal Science and Technology,China Agricultural University,Beijing 100193,China;

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Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed sheep

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