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Novel metabolic and physiological functions of branched chain amino acids: a review

机译：支链氨基酸的新型代谢和生理功能：综述

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摘要

It is widely known that branched chain amino acids (BCAA) are not only elementary components for building muscle tissue but also participate in increasing protein synthesis in animals and humans.BCAA (isoleucine,leucine and valine) regulate many key signaling pathways,the most classic of which is the activation of the mTOR signaling pathway.This signaling pathway connects many diverse physiological and metabolic roles.Recent years have witnessed many striking developments in determining the novel functions of BCAA including:(1) Insufficient or excessive levels of BCAA in the diet enhances lipolysis.(2) BCAA,especially isoleucine,play a major role in enhancing glucose consumption and utilization by up-regulating intestinal and muscular glucose transporters.(3)Supplementation of leucine in the diet enhances meat quality in finishing pigs.(4) BCAA are beneficial for mammary health,milk quality and embryo growth.(5) BCAA enhance intestinal development,intestinal amino acid transportation and mucin production.(6) BCAA participate in up-regulating innate and adaptive immune responses.In addition,abnormally elevated BCAA levels in the blood (decreased BCAA catabolism) are a good biomarker for the early detection of obesity,diabetes and other metabolic diseases.This review will provide some insights into these novel metabolic and physiological functions of BCAA.
机译：众所周知，支链氨基酸（BCAA）不仅是构成肌肉组织的基本成分，而且还参与增加动物和人类的蛋白质合成。BCAA（异亮氨酸，亮氨酸和缬氨酸）调节许多关键的信号通路，最经典近年来，在确定BCAA的新功能方面出现了许多惊人的进展，其中包括：（1）饮食中BCAA的水平过低或过高增强脂解作用。（2）BCAA，尤其是异亮氨酸，通过上调肠道和肌肉葡萄糖转运蛋白而在增加葡萄糖消耗和利用方面起主要作用。（3）日粮中添加亮氨酸可提高肥育猪的肉质。（4） BCAA有利于乳腺健康，牛奶品质和胚胎的生长。（5）BCAA促进肠道发育，肠氨基酸转运（6）BCAA参与上调先天和适应性免疫反应。此外，血液中BCAA异常升高（BCAA分解代谢降低）是早期发现肥胖，糖尿病和其他代谢疾病的良好生物标志物本文将对BCAA的这些新陈代谢和生理功能提供一些见解。

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  • 来源
    《畜牧与生物技术杂志(英文版)》 |2017年第3期|501-512|共12页
  • 作者

    Shihai Zhang; Xiangfang Zeng; Man Ren; Xiangbing Mao; Shiyan Qiao;

  • 作者单位

    State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,No.2 Yuanmingyuan West Road,Haidian District,Beijing 100193,People's Republic of China;

    College of Animal Science,South China Agricultural University,Wushan Avenue,Tianhe District,Guangzhou 510642,People's Republic of China;

    State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,No.2 Yuanmingyuan West Road,Haidian District,Beijing 100193,People's Republic of China;

    College of Animal Science,Anhui Science & Technology University,No.9 Donghua Road,Fengyang 233100,Anhui Province,People's Republic of China;

    Animal Nutrition Institute,Key Laboratory of Animal Disease-Resistance Nutrition,Ministry of Education,Sichuan Agricultural University,Ya'an,Sichuan,China;

    State Key Laboratory of Animal Nutrition,College of Animal Science and Technology,China Agricultural University,No.2 Yuanmingyuan West Road,Haidian District,Beijing 100193,People's Republic of China;

  • 收录信息 中国科学引文数据库(CSCD);
  • 原文格式 PDF
  • 正文语种 eng
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