Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn, Mn, and Cu from amino acid complexes and Co from Co glucoheptonate

Fernanda Batistel; Johan S.Osorio; Muhammad Rizwan Tariq; Cong Li; Jessica Caputo; Michael T.Socha; Juan J.Loor

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Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn, Mn, and Cu from amino acid complexes and Co from Co glucoheptonate

机译：补充了氨基酸配合物的Zn，Mn和Cu以及葡萄糖庚酸钴的Co的围产期奶牛，炎症和氧化应激的外周白细胞和子宫内膜分子生物标志物发生了改变

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Background:Immune dysfunction and a higher risk of uterine infections are characteristics of the transition into lactation in dairy cows.The supply of complexed trace minerals,which are more bioavailable,could help overcome the greater needs of these nutrients in tissues around parturition and early lactation.Results:Twenty Holstein cows received an oral bolus with a mix of inorganic trace minerals (INO) or complexed trace minerals (AAC) to achieve 75,65,11,and 1 ppm supplemental Zn,Mn,Cu,and Co,respectively,in the total diet dry matter from-30 d through +30 d relative to parturition.Blood for polymorphonuclear leukocyte (PMNL) isolation was collected at-30,-15,+10,and + 30 d relative to parturition,whereas endometrium biopsies were performed at +14 and +30 d.Feeding AAC led to greater PMNL expression of genes related with inflammation response (DDX58),oxidative stress response (MPO),eicosanoid metabolism (PLA2G4A and ALOX5AP),transcription regulation (PPARG),and cellular adhesion (TLN1).The upregulation by AAC in endometrium of genes related with inflammation response (TLR2,TLR4,NFKB1,TNF,IL6,IL1B,IL10,IL8),prostaglandin synthesis (PTGS2,PTGES),and antioxidant responses (NFE2L2,SOD1) indicated a faster remodeling of uterine tissue and potentially greater capacity to control a local bacterial invasion.Conclusions:Data indicate that trace mineral supplementation from amino acid complexes improves PMNL activity and allows the prompt recovery of uterine tissue during early lactation.As such,the benefits of complexed trace minerals extend beyond an improvement of liver function and productive performance.

机译：背景：免疫功能低下和子宫感染的高风险是奶牛向泌乳期过渡的特征。复合微量矿物质的供应（生物利用度更高）可以帮助解决分娩和早期泌乳前后组织中对这些营养素的更大需求。结果：20头荷斯坦奶牛接受了一次口服推注，混合了无机微量矿物质（INO）或复合微量矿物质（AAC），分别获得75、65、11和1 ppm的补充锌，锰，铜和钴，相对于分娩而言，从30 d到+30 d的总饮食干物质中分离出多形核白细胞（PMNL）的血液。相对于分娩，在30，-15，+ 10和+ 30 d收集了分离的子宫内膜活检标本。在+14和+30 d时进行。进食AAC导致与炎症反应（DDX58），氧化应激反应（MPO），类花生酸代谢（PLA2G4A和ALOX5AP），转录调控（PPARG）和细胞粘附相关的基因的PMNL表达更高（TLN 1）.AAC在子宫内膜上调与炎症反应相关的基因（TLR2，TLR4，NFKB1，TNF，IL6，IL1B，IL10，IL8），前列腺素合成（PTGS2，PTGES）和抗氧化反应（NFE2L2，SOD1）结论：数据表明，氨基酸复合物中微量矿物质的补充改善了PMNL的活性，并在早期泌乳期间可以迅速恢复子宫组织。复杂的微量元素不仅可以改善肝脏功能和生产性能。

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《畜牧与生物技术杂志(英文版)》 |2017年第4期|885-896|共12页
作者
Fernanda Batistel; Johan S.Osorio; Muhammad Rizwan Tariq; Cong Li; Jessica Caputo; Michael T.Socha; Juan J.Loor;
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Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA;

Department of Dairy Science, South Dakota State University, Brookings, SD, USA;

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA;

Department of Food Science and Technology, University College of Agriculture & Environmental Sciences, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan;

College of Animal Science and Technology, Key Laboratory of Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, China;

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA;

Zinpro Corporation, Eden Prairie, MN, USA;

Department of Animal Sciences and Division of Nutritional Sciences, University of Illinois, 1207 West Gregory Drive, Urbana, IL 61801, USA;

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Peripheral leukocyte and endometrium molecular biomarkers of inflammation and oxidative stress are altered in peripartal dairy cows supplemented with Zn, Mn, and Cu from amino acid complexes and Co from Co glucoheptonate

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