The roles of microRNAs in regulation of mammalian spermatogenesis

Xiaoxu Chen; Xueliang Li; Jiayin Guo; Pengfei Zhang; Wenxian Zeng

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The roles of microRNAs in regulation of mammalian spermatogenesis

机译：microRNA在调节哺乳动物精子发生中的作用

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Mammalian spermatogenesis contains three continuous and organized processes,by which spermatogonia undergo mitosis and differentiate to spermatocytes,follow on meiosis to form haploid spermatids and ultimately transform into spermatozoa.These processes require an accurately,spatially and temporally regulated gene expression patterns.The microRNAs are a novel class of post-transcriptional regulators.Cumulating evidences have demonstrated that microRNAs are expressed in a cell-specific or stage-specific manner during spermatogenesis.In this review,we focus on the roles of microRNAs in spermatogenesis.We highlight that N6-methyladenosine (m6A) is involved in the biogenesis of microRNAs and miRNA regulates the m6A modification on mRNA,and that specific miRNAs have been exploited as potential biomarkers for the male factor infertility,which will provide insightful understanding of microRNA roles in spermatogenesis.

机译：哺乳动物的精子发生过程包括三个连续而有组织的过程，精原细胞经历有丝分裂并分化为精子细胞，继而通过减数分裂形成单倍体精子并最终转化为精子。这些过程需要准确，时空调节的基因表达方式。越来越多的证据表明，microRNA在精子发生过程中以细胞特异性或阶段特异性方式表达。在本综述中，我们着眼于microRNA在精子发生中的作用。我们着重指出N6-甲基腺苷（ m6A）参与microRNA的生物发生，而miRNA调节mRNA上的m6A修饰，并且特定的miRNA已被用作雄性因子不育症的潜在生物标记，这将提供对microRNA在精子发生中作用的深刻理解。

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《畜牧与生物技术杂志(英文版)》 |2017年第4期|779-786|共8页
作者
Xiaoxu Chen; Xueliang Li; Jiayin Guo; Pengfei Zhang; Wenxian Zeng;
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College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China;

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China;

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China;

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China;

College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, China;

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The roles of microRNAs in regulation of mammalian spermatogenesis

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