Objective:To compare the efficacy and safety of antegrade and retrograde radical retropubic prostatectomy in the treatment of localized prostate cancer.Methods:Seventy patients with localized prostate cancer were randomly divided into the antegrade and retrograde groups(35 cases each group),and treated with antegrade and retrograde radical retropubic prostatectomy,respectively.The age,prostate volume,prostate-specific antigen,Gleason score,peroperative bleeding,operation time,postoperative pathological staging, following-up time,operation complication,and postoperative maximum urinary flow rate,sexual life recovery,biochemical recurrent time and number between two groups were compared.Results:No death in two groups was found.The differences of the age,prostate volume, prostate-specific antigen,Gleason score,pathological staging,following-up time,operation complication,and postoperative maximum urinary flow rate,biochemical recurrent number and sexual life recovery between two groups were not statistically significant(P >0.05).The operation time and peroperative bleeding in antegrade group were significantly less than those in retrograde group(P 0.05),但顺行根治性前列腺切除治疗局限性 PCa术中手术时间和术中出血量明显少于逆行根治性前列腺切除术 (P <0.01),最大尿流测定时间、生化复发时间均短于逆行根治性组(P<0.05~P<0.01).结论:耻骨后顺行与逆行根治性前列腺切除术均是治疗局限性PCa安全、有效的方法,但顺行根治性前列腺切除术治疗局限性PCa比逆行根治性前列腺切除术的术中出血更少,手术时间更短.
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