目的:探讨肝切除术早期应用乌司他丁对肝功能保护临床疗效的Meta分析.方法:检索Cochrane Database of Systematic Reviews 2011年第1期、PubMed(2000～2011)、EMbase(2000～2011)、CBMdisc(2000～2011)、CNKI(2000～2011)、VIP(2000-2011)中关于肝切除术早期应用乌司他丁对肝功能的保护作用的随机对照试验(randomized controlled trial,RCT),同时筛检纳入文献的参考文献.由3名研究者对文献质量进行严格评价和资料提取,对符合质量标准的RCT进行Meta分析.结果:共纳入5个RCT,共356例患者.Meta分析的结果显示,与对照组比较,肝切除同时应用乌司他丁组患者的血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆汁酸水平于术后1、3 d均下降(P<0.05~P<0.01).结论:肝切除术早期应用乌司他丁对肝功能具有保护作用.%Objective: To do Meta-analysis and assess the efficacy of ulinastatin in patients with hepatectony of randomized controlled trials(RCTs). Methods: RCTs were located through electronic databases of the Cochrane Database of Systanatic Reviews, MEDLINE (2000 -2011), EMbase(2000 -2011), CBMdiso(2000 -2011), CNKI(2000 -2011) and VIP(2000 -2011). Quality assesament and data abstraction were perforned by three reviews independently. Meta-analysis was conducted for the eligible RCTs. Results: Five RCTs were included Meta-analysis indicated that the levels of alanine aninotransferase, aspartate aminotransferase and total bile acid were decreased significantly in patients with ulinastatin treatment on the early postoperative time( the first day and third day) after hepatectany. Significant heterogeneity was existed between the pooled studies(P <0. 05 to P <0. 01). Conclusions: Application of ulinastatin after resection of liver has a positive effect on liver function.
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