减数分裂重组并非以统一的频率发生在基因组上,而是在某些区域重组频率较高,在另一些区域重组频率较低.减数分裂重组位点的刻画与识别对于认识重组机制具有重要意义.提出了一种新的DNA序列的3-D图形表示,并将其与Z-曲线相结合,借助正规化的ALE指标,用13维特征向量来刻画DNA序列进而进行减数分裂重组位点识别.以支持向量机作为分类器,利用夹克刀方法进行交互验证,所提方法的总精确度 Acc 达到了93.70%,相关系数MCC达到了0.873.这个结果表明此方法可作为减数分裂重组位点识别领域的一个有力工具.%The meiotic recombination events do not occur with a uniform frequency throughout the genome but with a higher rate in some regions and lower in others.Characterization and identification of meiotic recombination spots is critical for our understanding of the recombination mechanism.In this paper,we first propose a new 3-D graphical representation for a DNA sequences.Then,com-bining the 3-D graphical representaion with Z-curve, we characterize a DNA sequence by a 13-D vector whose components are the corresponding normalized ALE indices.Support vector machine(SVM)and Jackknife cross-validation test are employed to perform our method on a benchmark dataset for recombination spots.Results show that our method achieved an overall accuracy of 93.70%with the Matthew′s correlation coefficient(MCC)of 0.873,which suggests that the proposed method can serve as a useful tool for identifying the recombination spots.
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