Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats

Achint; Jain; Royana; Singh; Saurabh; Singh; Sanjay; Singh

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Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats

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The present study was undertaken to investigate the effect of diacerein on the histopathology of articular cartilage and subchondral bone of the femorotibial joint in rats.Osteoarthritis was induced in rats after single intra-articular injection of sodium iodoacetate.Rats were sacrificed 1,2,4,and 8 weeks post intra-articular injection to evaluate the progression of histopathogenesis of osteoarthritis.Diacerein was orally administered(15 mg/kg) once daily post1 and 2 weeks of iodoacetate injection in two groups,respectively,for up to 12 weeks.Articular cartilage and subchondral bone of the rats of both groups were examined after 8 and 12 weeks,respectively.Quantitative histological analyses were performed by scoring these sections as per the OARSI system.Chondroitin sulfate was also estimated in articular cartilage by decrease in absorbance of methylene blue on complexation with chondroitin sulfate using a spectrophotometer.Intra-articular injection of iodoacetate induced loss of articular cartilage with progressive subchondral bone sclerosis and degeneration.Based on histopathological and biochemical findings,diacerein treatment showed chondroprotective effect.Furthermore,the chondroprotective effect of diacerein was found to be more pronounced after 12 weeks as compared to 8 weeks in both cases(i.e.,post 1 and 2 weeks of iodoacetate injection).Similar results were observed by investigation of chondroitin sulfate during biochemical study,showing the chondroprotective effect.In conclusion,diacerein exhibits chondroprotective effect in rats with late onset of action.

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《生物医学研究杂志：英文版》 |2015年第005期|P.405-413|共9页
作者
Achint; Jain; Royana; Singh; Saurabh; Singh; Sanjay; Singh;
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作者单位

[1]Department of Pharmaceutics, Indian Institute of Technology;

[2]Departmant of Anatomy;

[3]Departmant of Orthopedics, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221 005, U.P. India;

[4]National Institute of Pharmaceutical Education ＆ Research, Raebareli-229 010, U.P. India;

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原文格式 PDF
正文语种 CHI
中图分类基因在蛋白质合成中的作用;
关键词
骨性关节炎; 醋酸钠; 大鼠; 诱导; 组织病理学; 关节软骨; 分光光度计; 碘;

机译：骨性关节炎;醋酸钠;大鼠;诱导;组织病理学;关节软骨;分光光度计;碘;

Diacerein protects against iodoacetate-induced osteoarthritis in the femorotibial joints of rats

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