Preliminary feasibility and hemodynamic performance of a newly- developed self-expanding bioprosthesis and 16-F delivery system in  transcatheter aortic valve implantation in sheep

Jing Cai; Yanhui Sheng; Shijiang Zhang; Wei Sun; Rong Yang; Liping Miao; Xiangqing Kong

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Preliminary feasibility and hemodynamic performance of a newly- developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep

机译：一种新开发的自扩展生物假体和16-F输送系统在羊经导管主动脉瓣植入术中的初步可行性和血液动力学性能

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We sought to evaluate the feasibility and hemodynamic performance of a new self-expanding bioprosthesis and 16-F delivery system in sheep.A 23-mm new self-expanding aortic bioprosthesis was implanted in sheep(n = 10) with a 16-F catheter via the right common carotid artery.Each sheep underwent angiography and coronary angiography before intervention,immediately and 1 h after stent implantation.Electrocardiographic monitoring was carried out during and 2 h after the procedure.Transthoracic echocardiography was employed to detect hemodynamic performance before intervention,immediately and 1 and 2 h after stent implantation.All sheep were euthanized 2 h after successful implantation for macroscopic inspection.In all cases,the new self-expanding aortic bioprosthesis was successfully delivered to the aortic root and released with a 16-F catheter.Successful implantation was achieved in 8 of 10 sheep.Hemodynamic performance and device position of successful implantation were stable 2 h after device deployment.Atrioventricular block was not observed.We conclude that it is feasible to implant the new self-expanding aortic valve with a 16-F delivery system into sheep hearts via the retrograde route.

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《生物医学研究杂志：英文版》 |2012年第003期|P.211-218|共8页
作者
Jing Cai; Yanhui Sheng; Shijiang Zhang; Wei Sun; Rong Yang; Liping Miao; Xiangqing Kong;
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作者单位

^pof;

Cardiology,;

the;

First;

Affiliated;

Hospital,;

Nanjing;

Medical;

University,;

Nanjing,;

Jiangsu;

210029,;

China.;

^pof;

Cardiac;

Surgery,;

the;

First;

Affiliated;

Hospital,;

Nanjing;

Medical;

University,;

Nanjing,;

Jiangsu;

210029,;

China.;

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原文格式 PDF
正文语种 CHI
中图分类组织学;
关键词
动力学性能; 输送系统; 主动脉; 生物瓣; 绵羊; 植入; 血流; 导管;

机译：动力学性能;输送系统;主动脉;生物瓣;绵羊;植入;血流;导管;

Preliminary feasibility and hemodynamic performance of a newly- developed self-expanding bioprosthesis and 16-F delivery system in transcatheter aortic valve implantation in sheep

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