The serum levels of MMP-9, slCAM-1, CRP and WBC increased in patients with acute coronary syndrome

Hong Jin; Geng Peng; Dongming Wang; Chuanzhe Yue; Yuguang Li

首页> 中文期刊> 《生物医学研究杂志（英文版）》 >The serum levels of MMP-9, slCAM-1, CRP and WBC increased in patients with acute coronary syndrome

The serum levels of MMP-9, slCAM-1, CRP and WBC increased in patients with acute coronary syndrome

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective :To evaluate the association of the peripheral levels of the defined inflammatory markers with different types of acute coronary syndrome (ACS) and stable angina, and the role inflammation played in the pathogenesis of ACS. Methods :For understanding the variation of serum concentrations of matrix metalloproteinase-9 (MMP-9), soluble intercellular adhesion molecule-1(sICAM-1), C-reactive protein (CRP), and white blood cell count(WBC) and their association with ACS, 90 patients with coronary heart disease (CHD) and 30 healthy volunteers were recruited. The enrolled people were assigned into four equal groups, including acute myocardial infarction (AMI) group, unstable angina pectoris (UAP) group, stable angina pectoris (SAP) group and healthy control group. The serum levels of MMP-9 and sICAM-1 were measured with ELISA kits, CRP were measured with im munoturbidimetric assay, and WBC number were assessed all before any treatment was administrated. Results: (1)The serum levels of MMP-9, sICAM-1 ,CRP and WBC in the patients with ACS were significantly higher than those in the control group(P ＜ 0.01). (2)Compared with control group, patients with SAP only had higher serum level of sICAM-1 (P ＜ 0.01). While the levels of MMP-9, CRP, and WBC had no significant difference between them (P ＞ 0.05 all). (3)Significant positive correlation between the serum levels of MMP-9 and sICAM-1 and CRP and WBC all were observed in the patients with ACS (P ＜ 0.05).Conclusion: The elevation of serum concentrations of inflammatory markers including MMP-9, sICAM-1, CRP and WBC were associated with initiation and progression of ACS, and they may help predicting cardiovascular events.

著录项

来源
《生物医学研究杂志（英文版）》 |2007年第4期|222-226|共5页
作者
Hong Jin; Geng Peng; Dongming Wang; Chuanzhe Yue; Yuguang Li;
展开▼
作者单位

Department of Cardiology, the First Affiliated Hospital to Medical College of Shantou University, Shantou 515041,Guangdong Province, China;

Department of Cardiology, the First Affiliated Hospital to Medical College of Shantou University, Shantou 515041,Guangdong Province, China;

Department of Cardiology, the First Affiliated Hospital to Medical College of Shantou University, Shantou 515041,Guangdong Province, China;

Department of Cardiology, the First Affiliated Hospital to Medical College of Shantou University, Shantou 515041,Guangdong Province, China;

Department of Cardiology, the First Affiliated Hospital to Medical College of Shantou University, Shantou 515041,Guangdong Province, China;

展开▼
原文格式 PDF
正文语种 chi
中图分类内科学;
关键词
acute coronary syndrome; matrix metalloproteinase-9; soluble intercellular adhesion molecule-1; C-reactive protein; white blood cell count;

机译：急性冠状动脉综合征;基质金属蛋白酶-9;可溶性细胞间粘附分子-1;C-反应蛋白;白细胞计数;

The serum levels of MMP-9, slCAM-1, CRP and WBC increased in patients with acute coronary syndrome

摘要

著录项

相关主题

期刊订阅