目的:探讨呼吸门控(active breathing control,ABC)技术以及非均整(Flattening Filter Free,FFF)模式治疗技术治疗早期非小细胞肺癌较传统立体定向放射治疗( stereotactic body radiation therapy,SBRT)在治疗总时间、摆位误差以及剂量学等方面的优势.方法:选取2017～2018年度哈尔滨医科大学附属肿瘤医院放疗技术中心收治的早期非小细胞肺癌小病灶的患者(n=26),根据治疗模式,将研究对象分为A组(均整模式下SBRT,n=10)、B组(FFF模式下SBRT,n=8)、C组(FFF模式下应用ABC技术的SBRT,n=8),同时收集各组患者的摆位误差数据,并分析其左右、头脚、前后三个方向上测量的误差. A组:均整模式下SBRT治疗后通过配准图像获取的数据;B组:FFF模式下SBRT后通过配准图像获取的数据;C组:FFF模式下应用ABC技术的SBRT治疗后通过配准图像获取的数据;比较3组患者的治疗时间、摆位误差、单次剂量、靶区勾画以及患侧肺V5 、V20及剂量学差异.结果:C组治疗总时长较短,与B组无明显差异,单位时间内的治疗出束跳数明显高于A组,总时间比A组缩短了1倍(P0. 05). Machine unit／TTT in group C was significantly more than that in group A. The setup error in group C was the smallest (P<0. 05). V5 and V20 of the affected lobe in group C were lower than that in group A and that in group B (P<0. 05). Conclusion: Active breathing control and FFF techniques have obvious advantages in the treatment of early-stage NSCLC with small lesions such as shorter treatment time, higher patient comfort, smaller error and better protection for the affected lobe.
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