Objective To analyze the surgical outcomes of 72 infants with ventricular septal defect (VSD) and pulmonary artery hypertension ( PAH), and to explore the impact of factors on curative effect of surgical treatment.Methods Seventy-two infants with VSD and PAH were operated with extracorporeal circulation in hypothermia from January 2011 to June 2014 in the General Hospital of Ningxia Medical University .Patch repairs were performed in 53 cases of VSD ( Dacron 48 cases,autologous pericardium 5 cases),and direct suture was performed in 19 cases of VSD.The cases of ASD and PDA were received direct suture .Results Sixty-six infants with VSD and PAH were cured,and 2 infant died from low cardiac output syndrome ,4 infants couldn′t deviate from ventilator.The hospital mortality was 8.33%.Follow-up was completed in all 66 survived infants for 3 months to 3 years,and all developed well.Conclusions Infants with VSD and PAH should be operated on as early as possible . Active support treatment should be taken before and after the operation ,and careful operation should be taken in surgical procedures.These measures can effectively reduce mortality and postoperative complications of the surgery in infants.%目的探讨总结影响婴幼儿室间隔缺损合并肺动脉高压外科治疗疗效的因素。方法分析72例10 kg 以下婴幼儿室间隔缺损合并肺动脉高压的手术结果。2011年1月至2014年6月宁夏医科大学总医院对72例室间隔缺损合并肺动脉高压患儿采用全麻体外循环（中度低温、中低流量）下行室间隔缺损修补术，室间隔缺损采取补片修补53例（其中 Dacron 片48例，自体心包5例），直接缝合19例；房间隔缺损和动脉导管未闭予以直接缝闭。结果治愈66例，死于低心排出量综合征2例，术后脱呼吸机困难死亡4例，病死率8．33％。66例患儿术后随访3个月至3年，未见其他并发症和死亡病例。结论10 kg以下婴幼儿室间隔缺损合并肺动脉高压经术前治疗和准备后，应及时手术治疗，术中体外循环管理和保障、精细操作，以及良好的术后处理可有效地降低手术致死率和术后并发症发生率。
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