Neuropathic pain is a class of pain caused by an injury or diseases of the somatosensory system and characterized by spontaneous pain,allodynia,and hyperalgesia.It is well established that central sensitization is one of the key mechanisms underlying the development and maintenance of neuropathic pain.Cannabinoid receptor 1 (CB1R) of endocannabinoid system modulates synaptic transmission,regulates synaptic plasticity,inhibits central sensitization,and thus attenuates neuropathic pain.Recent studies have shown that activation of CB1R also involves in the relief of neuropathic pain-induced depression.%神经病理性疼痛是一类由躯体感觉系统损伤或疾病导致的以自发痛、痛觉过敏和痛觉超敏为特征的疼痛,目前认为中枢敏化是神经病理性疼痛产生和维持的关键机制之一.内源性大麻素系统的大麻素受体1可调控神经递质的释放,改变突触可塑性,进而抑制中枢敏化,可减轻神经病理性疼痛此外,大麻素受体1激活亦可缓解神经病理性疼痛所致的抑郁.
展开▼
