The Ras genes widely exist in nature, Ras-GRF1 proteins in cell signal transduction, cell differentiation and growth play a very important role. Previous researchs have shown that the Ras genes are closely associated with signal-ing pathways and learning and memory function. This research was study to companed the differences between the gene knockout Ras-GRF1 and will rats on learning and memory by the behavior experiments. It was found that Ras-GRF1 knockout mice learning memory ability weak in wild type mice by Morris water maze,etc.%Ras基因广泛存在于自然界中，其控制的Ras-GRF1蛋白在细胞信号传导，在细胞分化与生长过程中起着极其重要的作用。已有研究表明，Ras基因与信号通路和学习记忆功能密切相关。本实验利用行为学研究敲除Ras-GRF1基因的小鼠在学习记忆上与野生老鼠的差异，通过Morris水迷宫等实验发现Ras-GRF1基因敲除小鼠的学习记忆能力弱于野生型小鼠。
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