Camptothecine solubility in dimethylsulfoxide-methanol/ethanol mixed solvents was measured over temperature range of 274.50~326.00 K under atmospheric pressure. The experimental results show that the solubility of camptothecine in the mixed solvents increases with the increase of temperature and dimethylsulfoxide mole fraction. The experimental solubility data are well correlated with a modified Apelblat equation, λh equation and ideal equation, respectively. The Akaike’s Information Criterion (AIC) was used to select the best model for correlation. The dissolution enthalpy, entropy and Gibbs free energy change of camptothecine are calculated using the measured solubility.%采用重量法测定了喜树碱(camptothecine，CPT)在二甲亚砜(dimethylsulfoxide, DMSO)+甲醇(或乙醇)混合溶剂中的溶解度，温度范围是274.50~326.00 K。在混合溶剂中CPT的溶解度随温度的升高而增大，随混合溶剂中DMSO摩尔分数含量的增大而增大。分别用修正Apelblat方程、λh方程和理想状态方程进行关联，关联效果令人满意，获得了相关模型参数。相对而言，λh方程关联的效果较好。根据溶解度数据和修正的Apelblat方程计算出溶解焓、溶解熵和吉布斯自由能。
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