目的：探讨帕金森病（Parkinson’s disease，PD）患者血浆同型半胱氨酸（Homocysteine，Hcy）水平与认知功能障碍的相关性。方法选取106例PD患者（包含认知障碍者55例，认知正常者51例）及50例健康对照者，收集临床资料、认知功能评估，应用高效液相色谱法测定血浆Hcy浓度，放射免疫法测定血浆叶酸、维生素B12浓度，分析血浆Hcy含量与认知功能的相关性。结果认知障碍组血浆Hcy值显著高于认知正常组，差异具有统计学意义（P＜0.05），两组血浆叶酸、维生素B12浓度无统计学差别。PD认知障碍组简易智能状态量表评分及蒙特利尔认知评估量表评分均与血浆Hcy值存在显著负相关。结论血浆Hcy升高与PD认知功能障碍存在显著相关性，血浆Hcy升高可能是PD认知损害的一个风险因子。%Objective To study the association between the level of plasma homocysteine(Hcy) and the cognitive dysfunction in patients with Parkinson’s disease(PD).Methods Total 156 subjects were enrolled, including 50 unrelated healthy controls and 106 patients with PD. The basic information, disease situation and cognitive function of patients with PD were investigated and the plasma concentrations of Hcy, folic acid and vitamin B12 were detected in each subject. The relationship between plasma Hcy levels and the cognitive function was assessed.Results The plasma Hcy concentrations of cognitive dysfunction group were higher than those of normal cognitive group [(21.5±5.1)μmmol/L vs(14.7±4.7)μmmol/L,P<0.05] and there were no differences in plasma concentrations of folic acid and vitamin B12 among the groups. The scores of the Mini-mental state examination(MMSE) and Montreal cognitive assessment(MoCA) all showed significant correlations with plasma Hcy in patients with PD.Conclusion The elevated plasma Hcy level is significantly associated with the cognitive dysfunction.The increase of plasma Hcy maybe one of the main important risk factors of cognitive dysfunction in PD patients.
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