Over the past 8 years, the commercial collision/reaction cell with inductively coupled plasma mass spectrometry (ICP-MS) has been developed and improved continuously. The commercial cell devices benefit from the original fundamental framework on the collision cell. Now the processes and principle of the collision or reaction are clearer than before. There are two approaches for collision/reaction cell technology to overcome spectral interference problem in ICP-MS: a) remove isobaric interference; b) shift the analyt to less interference mass. The kinetic energy discrimination effect and bandpass has been applied respectively on different multipole cell for ejecting the undesirable interferences species produced within cell. The cell gas selection is depend on which interference species want to be compressed and the working characteristics of the cell. To meet most routine task for a wide range of multi-element measurement, a new approach is developed and work on two mixed gas mode switching. An additional important characteristic with the cell (collision focusing) has been noticed and applied to get excellent precision in isotope ratio measurement.
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