A recent feature of global drug markets is the unprecedented pace at which new psychoactive substances (NPS) have been developed and emerged worldwide.Synthetic opioids represent a class of NPS, which mostly consist of the prescription drug fentanyl and its analogues.Use of illicitly manufactured fentanyl and its analogues amplifies the hazards because lack of quality control for these products, which are not portioned in precise doses, and can be deadly in minuscule amounts due to the extreme potencies.The mass-spectral fragmentations of these compounds following electron ionization (EI) and electrospray ionization (ESI) under collision-induced dissociation (CID) mode were studied to obtain the fragmentation characteristics of fentanyl analogues.Compounds were analyzed on Aglient DB-5 MS column (30 m×0.25 mm×0.25μm) with an initial temperature of 60℃for gradient increased temperature by GC/MS, and Acquity UPLC CSHTM C18 column (10 cm×2.1 mm×1.7μm) with 0.1％formic acid aqueous solution (A) -acetonitrile (B) as mobile phase for gradient elution by UPLC-Q-TOF MS.According to the structure and the typical fragmentations, these compounds could be easily identified.The countless possibilities to create new fentanyl analogues by small changes in chemical structures pose a growing challenge to forensic analysts.So this work will be helpful to assist forensic laboratories in identifying these kinds of compounds or other substances with similar structure in case work.%采用气相色谱-质谱 (GC/MS) 法和超高效液相色谱-串联四极杆飞行时间质谱 (UPLC-Q-TOF MS) 法对20152016年国内检测发现的8种芬太尼类新精神活性物质进行分析.GC/MS分析采用电子轰击源 (EI) 模式采集数据, UPLC-Q-TOF MS分析采用电喷雾正离子碰撞诱导解离 (CID) 模式采集数据.通过总结该类物质在两种模式下获得的碎片离子与分子结构的关系, 推测其可能的碎裂途径, 并归纳了通过谱图推导未知芬太尼类新精神活性物质结构的方法, 结果可为该类物质的鉴定提供参考.
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