Objective To evaluate the 7th edition American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumor node metastasis (TNM) staging system for gastric carcinoma with the 6th edition in Chinese population.Methods A total of 401 gastric cancer patients undergoing surgical resection was staged using the 6th and 7th edition AJCC TNM staging system,respectively.Homogeneity,discriminatory ability,and monotonicity of gradients of two systems were compared using linear trend x2 test,likelihood ratio x2 statistics,and akaike information criterion (AIC) calculations.To compare the accuracy of prognostic evaluation between the 6th and the 7th edition TNM staging system for gastric cancer.Results Significant difference in 5 years survival rate were observed according to the T/N classification using the 6th edition staging system,and there were similar survival curves between T1a and T1b according to the 7th T classification.There was not significant difference between the area under the curve (AUC) of the 6th and the 7th edition staging systems.Conclusions T staging and N classification according to the 7th edition showed better performance,but the 72 TNM staging system was not better in predictive accuracy.%目的 评估6th/7th美国癌症联合委员会/国际抗癌联盟(AJCC/UICC)胃癌分期系统的临床适用性.方法 对纳入研究的401例胃癌术后患者分别按照6th/7th分期标准分期.采用线性趋势x2检验、似然比x2检验、赤池信息准则和ROC曲线下面积对两版分期系统进行评估.结果 6thT、N各分期组间5年生存率差异有统计学意义(P＜0.05),7thT分期T1a/b组间差异无统计学意义(P＞0.05).6th/7thT、N分期(5个亚组)AUC比较差异有统计学意义(P＜0.05).6thTNM分期系统赤池信息准则(AIC)小于7thTNM分期系统,AUC比较差异无统计学意义(P＞0.05).结论 7thT分期、N分期优于6th分期标准,6th/7th综合分期系统预后判断价值差异无统计学意义(P＞0.05),6th 综合分期系统更简洁直观.
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