观察重症急性胆管炎(ACST)的病人凝血的变化。方法 对30例ACST的病人的临床资料进行回顾性分析。另选择30例胆囊结石手术病人作为对照组。结果 ACST组血浆中的内毒素(LPS)含量增高，PT和KPTT延长，血小板计数减少均较对照组有非常显著的差异(P＜0.01)，纤维蛋白原显著低于对照组(P＜0.01)。ECLT两组均无变化。结论 ACST的病人多有凝血障碍，随着病情好转上述结果可恢复正常。%Objective To study the changes of coagulation with severe acutecholangitis (ACST).Methods The clinical data of thirty patients with ACST were analyzed restrospectivly,another thirty patients with chlolecyst-lithiasis postoperation,as a control group.Results The plasma endotoxin increased,prothrombin time(PT) and kaolin partial thromboplastin time(KPTT) prolonged and platelet count decreased,there was signiticantly difference(P＜0.01),as compared with control group.Fibrinogen concentration in ACST group was lower than that in control group,euglobulin clot lysis time(ECLT) had not any significant change in two groups. Conclusions It suggests that coagulation disturbance was present in most of patients with ACST.When the patients recovery gradually,above abnormal changes can return to normal.
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