Fas介导的细胞凋亡在结肠癌发生机制中的作用。方法 采用流式细胞学方法测定不同组织Fas基因蛋白表达，结果 正常结肠组织Fas表达阳性率为(12.17±3.68)%，结肠癌组织Fas表达明显低于正常结肠粘膜及良性病变(P＜0.01)，炎症组织Fas基因表达则高于正常粘膜，Fas表达还与肿瘤的分化程度有关(P＜0.05)。结论 Fas介导的细胞凋亡在结肠癌发生过程中起着重要作用。%Objective To explore the role of Fas gene expression inpathogenesis of human colonic cancer tissue.Method Expression of Fas gene protein in benign and malignant colonic tissue was detected by using flow cytometry in forty patients.Results Expression rate of Fas in normal control mucosas was(12.17±3.68)%.The expression rate in colonic cancer tissue was lower than both normal control group and benign tissue.The expression rate in inflammatory tissue was higher than the normal mucosal tissue,and the expression rate was correlated with the tumor differentiation.Conclusions Fas-mediated apoptosis may play an important role in carcinogenesis of colonic tissue.
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