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首页> 中文期刊> 《中国医师杂志》 >经皮微波消融治疗子宫肌层良性病变的临床研究

经皮微波消融治疗子宫肌层良性病变的临床研究

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目的 研究经皮微波消融治疗子宫肌层良性病变的临床价值.方法 将2016年1月至2017年1月间本院收治的100例子宫肌层良性病变患者纳为研究对象,按入院先后顺序将其分为观察组(经皮微波消融,n=50)与对照组(子宫动脉栓塞术,n=50),观察两组围术期相关指标、术后不良反应发生率、血红蛋白(Hb)、血清糖类抗原125(CA125)、月经状况及随访结果.结果 观察组手术时间与下床活动时间均短于对照组(P＜0.05);观察组、对照组术后不良反应发生率分别为44.00％和100.00％ (P ＜0.05),1年复发率分别为4.00％和12.00％ (P ＞0.05);两组治疗1、3个月后,经期、经量及痛经程度得分均逐渐降低,组内差异有统计学意义(P＜0.05),与对照组对应时间点比较,观察组各指标得分更低,组间差异有统计学意义(P＜0.05);术后3、12个月,两组Hb水平逐渐增高,血清CA125浓度逐渐降低,组内差异有统计学意义(P＜0.05),与对照组各时间点比较,观察组各指标水平改善更为明显(P＜0.05);术后6、12个月,两组子宫体积及肌瘤体积均逐渐缩小,组内差异有统计学意义(P＜0.05),与对照组各时间点比较,观察组子宫及肌瘤体积更小(P＜0.05).结论 微波消融在子宫肌层良性病变中治疗安全性高,具有术后并发症少、恢复快、疗效确切的优势,值得临床推广.%Objective To study the clinical value of percutaneous microwave ablation of uterine myometrium benign lesions.Methods 100 cases of patients with benign lesions of myometrium in our hospital from January 2016 to January 2017 were enrolled in the study.According to the treatment methods,they were divided into observation group (percutaneous microwave ablation,n =50) and control group (uterine artery embolization,n =50).Relevant perioperative indicators,postoperative complications,hemoglobin (Hb),serum carbohydrate antigen 125 (CA125),menstrual status and follow-up results were observed in both groups.Results The operative time and ambulation time were significantly shortened in observation group (P ＜ 0.05).The postoperative adverse reaction rates in observation group and control group were 44.00％ and 100.00％ respectively (P ＜ 0.05),and the 1-year recurrence rates were 4.00％ and 12.00％ (P ＞0.05).After 1 month and 3 months of treatment,the menstrual period,menstrual volume and dysmenorrhea degree score were gradually decreased in the two groups,and the differences withingroups were significant (P ＜ 0.05).Compared with the corresponding time points of the control group,the level of each index in the observation group was lower,and there was significant difference between the two groups.At 3 months and 12 months after operation,the level of Hb in the two groups was gradually increased while the serum CA125 concentration was gradually decreased (P ＜ 0.05).Compared with the control group at each time point,the level of each index was better in observation group (P ＜ 0.05).At 6 months and 12 months after operation,the uterus volume and fibroid volume in the two groups were gradually decreased (P ＜ 0.05).Compared with the control group at each time point,the uterus volume and fibroid volume were smaller in observation group (P ＜ 0.05).Conclusions Microwave ablation has high safety in the treatment of benign lesions of myometrium,and it has the advantages of few postoperative complications,quick recovery and definite efficacy.Thus it is worthy of clinical promotion.

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