Objective:To observe the clinically curative effect of acupuncture treatment for alopecia areata and to explore the related mechanism from the aspects of CD4 +and CD8 +levels in peripheral blood.Methods:60 enrolled cases were divided into an acupuncture group and a western medicine group.30 cases were in each group randomly.The acupuncture group was treated by plum-blossom needle by means of local skin flushing mild bleeding,once every other day and body acupuncture once a day,20 mins a time, one month as a treatment course;the western medicine group was given 5%Minoxidil Tincture applied to the lesion,1 ml each time,two times a day,oral Vitamins with Minerals Tablets,one month as a treatment course.Results:After a course of treatment,the clinically therapeutic effect of acupuncture group was better than that of the western medicine group(P<0.05);the recurrence rate after three months was less than that of the western medicine group (P<0.05 );peripheral blood CD4 +,CD4 +/CD8 +levels in the acupuncture group were significantly improved com-pared with that of the western medicine group ( P <0 .05 ) .Conclusion:Acupuncture treatment for alopecia areata has an obviously curative effect and can significantly improve the immunological indexes in patients, which is probably one of the therapeutic mechanisms.%目的：观察针刺治疗斑秃的临床疗效，并从外周血CD4＋、CD8＋水平改变的角度探讨相关作用机理。方法：60例入选病例随机分为针刺组和西药组各30例。针刺组采用梅花针局部叩刺结合体针，梅花针叩刺以斑秃局部皮肤潮红轻度渗血为度，隔日1次，体针辨证取穴，留针20 min，每日1次，1个月为1个疗程；西药组给予5％米诺地尔酊涂抹患处，每次1 ml，每日2次，口服多维元素片，1个月为1个疗程。结果：经1个疗程治疗后，针刺组疗效明显优于西药组（P＜0．05），针刺组外周血CD4＋水平以及CD4＋／CD8＋值与西药组比较有显著改善（P＜0．05），3个月后随访复发率低于西药组（P＜0．05）。结论：针刺治疗斑秃有明显疗效，并且能显著改善患者免疫学指标，推测是其治疗机理之一。
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