目的 观察静脉注射速度对小儿罗库溴铵静脉注射痛反应的影响.方法 全麻下择期手术患儿60例均分为两组,给予咪唑安定、氯胺酮,入睡后给予罗库溴铵0.6 mg/kg(浓度10mg/ml).A组注速≤3 s,B组注速60 s.采用加速度肌松监测仪监测肌松指标,观察罗库溴铵静脉注射痛反应、气管插管条件和肌松起效时间.结果 B组静脉注射痛反应的发生率明显低于A组(P<0.01);两组插管条件和肌松起效时间的差异无统计学意义.结论 缓慢静脉注射罗库溴铵能明显减轻罗库溴铵静脉注射痛,对气管插管条件和肌松起效时间无明显影响.%Objective To compare the effects of rocuronium injection rates on rocuroniuminduced injection pain in children. Methods Sixty children undergoing general anesthesia were divided into two groups with 30 eases each. Anesthesia was induced with midazolam, ketamine and rocuronium 0.6 mg/kg. Rocuronium was injected within 3 seconds in group A or slowly in 60 seconds in group R The neuromuscular blockade was monitored by acceleromyography with train-of-four stimulation. The pain of rocuronium injection and intubation Conditions were assessed. Results The incidence and intensity of injection pain were significantly lower in group B than those in group A(P<0.01).The onset time and intubation conditions of two groups were similar. Conclusion The lower injection rate of rocuronium significantly reduces the incidence and intensity of injection pain without any effect on the onset time and intubation condition in children.
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