目的 分析利奈唑胺治疗危重结核性脑膜炎的效果及对患者脑脊液神经生长因子(NGF)及其受体的影响.方法 回顾性分析2012年1月至2015年12月诊治的II级和III级重症结核性脑膜炎患者资料.160例患者分为抗结核治疗组(n=80)和利奈唑胺十抗结核治疗组(n=80).比较两组患者治疗后脑脊液指标、GCS评分及脑脊液NGF和内皮素及其受体和白细胞介素水平.结果 抗结核治疗组和利奈唑胺十抗结核治疗组患者脑脊液糖/同步血糖、神经生长因子及其受体、GCS评分水平均明显升高(P <0.05),而脑脊液白细胞计数、内皮素及其受体、白细胞介素水平均明显降低(P <0.05),且利奈唑胺十抗结核治疗组患者变化较抗结核治疗组更显著(P <0.05).结论 利奈唑胺对危重结核性脑膜炎患者脑脊液指标及GCS评分有显著改善作用,可能与其调控患者脑脊液中NGF和内皮素及其受体、白细胞介素蛋白水平有关.%Objective To explore the clinical effect of linezolid on severe tuberculous meningitis patients and the influences on serum NGF and its receptors. Methods 160 cases of severe tuberculous meningitis patients in our hospital from Jan 2012 to Dec 2015 were enrolled in this study. The effect of linezolid on severe tuberculous meningitis patients and the influences on serum NGF,endothelin and their receptors,GCS scores as well as interleukins concentrations were assayed. Results The results showed that the CSF/blood glucose ration,NGF and its receptor, GSC scores were increased greatly after the mediaction of linezolid(P <0.05). At the same time,the serum endothelin and its receptor,inter-leukins and white blood cell counts were decreased greatly after the mediaction of linezolid(P <0.05). Conclusion Linezolid have a significant effect on GSC scores and indicators of cerebrospinal fluid in severe tuberculous meningitis patients which maybe related with the regulation of serum NGF and its receptors,interleukin protein.
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